Nathan Cleverly and Matthew Macklin will face former world title challengers on December 11 at Liverpool's Echo Arena.
Cleverly will challenge for the Interim WBO World light-heavyweight title against the number two ranked Alejandro Lakatos.
And Macklin will defend his European middleweight belt against Ruben Varon.
Part of a huge card to celebrate promoter Frank Warren's 30 years in boxing, the fights will feature alongside Paul Smith's British super-middeweight title defence against James DeGale.
Kell Brook, Tony Bellew and Frankie Gavin will also be in title action.
Born in Romania, tough Eastern European Lakatos is a two-time world title challenger with a wealth of experience.
Among his opponents have been unbeaten world champions Dariusz Michalczewski and Zsolt Erdei.
Spaniard Varon is equally dangerous, with a WBO world title challenge against Felix Sturm on his CV.
"Lakatos knows what it is all about and he will be a real threat," said Welsh sensation Cleverly.
"He's fought the best in the world so I can take nothing for granted, and I'll have to be very sharp on the night."
Macklin, who wants to press his claims for a world title shot with a win against Varon, added: "I've been saying for ages that Felix Sturm is the man that I want.
"If I can do a better job than him against Varon, it could start opening some doors for me.
"Varon will be really up for this fight though, so I can't afford to slip up."
