No he isn't. The only way you could make this argument is by ruling out Floyd based on his inactivity and lack of fights at welter and then there is a borderline case for saying that Calzaghe, in cleaning out Lacy and Kessler from SMW and the defeating Hopkins at LHW, has has won the most significant fights, captured titles and done so against Lacy and Kessler with two of the best performances in recent boxing history.
Even if we make this kind of argument though, we have to discount everything Mayweather has done previously in his career and I'm sure Manny Pacquiao would feel he has similar claims too, and I would tend to agree.
I think when Calzaghe beat Hopkins the p4p top 3 stayed the same:
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