The first thing I said to my son when I saw Spence come out was that he looks off, I asked him if he noticed it and he said yes, he never watches boxing or knew who Spence was.
Here are some comparison pictures. https://www.flickr.com/photos/154069931@N04/shares/dq7U57Z872
He looks high vs Crawford, color is off with eye bugs.
I very much doubt he would get high on the biggest fight of his life unless he's a complete moron, he was probably just a little overwhelmed with the occasion and didn't sleep so well or something i wouldn't look too much into it just not his night that's all.