Being that a heavyweight jab is like a cruiserweight right cross, the answer is yes. A jab from most any heavyweight could knock out a welter. It wouldn't, most of the time, but definitely could.
Well i weigh 235 and I put a LHW on his ass with a straight jab down the pibe, and he had helmet on, i have also broken 2 noses, so yes
My jab is heavy and fast, a right hook perfectly palced on the head from a fully fledge HW would end the fight