....You have to have brains inside of your head in order for you to get hurt. Margarito has a huge thick skull surrounding a pee brain. He cannot get damaged with that type of protection. It's like the stories you hear of people not being able to fend off Pit Bulls with a baseball bat. Floyd should stay retired.
Most likely not you need to outbox him to beat him or outwork him like Paul Williams but i think outworking him is a way harder route. Knocking him out is not an option most likely anyways and going into a fight with Margarito with thoughts of knocking him out is a huge mistake for a welter weight.