Jamaine Ortiz produced the most noteworthy victory of his six-year professional career in his last fight.

The undefeated lightweight out-boxed former WBO junior lightweight champion Jamel Herring and won a 10-round unanimous decision in a co-feature ESPN broadcast May 21 from Resorts World Las Vegas. Most oddsmakers have still installed Vasiliy Lomachenko as at least a 25-1 favorite to beat Ortiz in their 12-round main event Saturday night at Madison Square Garden’s Hulu Theater in New York (ESPN+; 10 p.m. ET).

Ortiz is undeniably a huge underdog entering his fight with a highly regarded three-division champion, yet Lomachenko hasn’t concerned himself with whether Ortiz is really ready for this gargantuan leap up in class.

“I’m not his promoter,” Lomachenko told BoxingScene.com, according to his translator. “I’m not his trainer. I’m not thinking about if this step up is too much for him or not. My goal is to win this fight and get closer to my goal of fighting for the undisputed title.”

If Ukraine’s Lomachenko (16-2, 11 KOs) overcomes Ortiz (16-0-1, 8 KOs), he could advance toward a showdown with undisputed lightweight champ Devin Haney at some point within the first half of 2023. Bob Arum, whose company promotes Haney (29-0, 15 KOs) and Lomachenko, wants to match them next if Lomachenko wins on Saturday night, though that’ll also depend on whether Haney remains in the 135-pound division.

First, of course, Lomachenko is concerned with opposing Ortiz, a Worcester, Massachusetts native who won a main event as part of Showtime’s prospect series, “ShoBox: The New Generation,” just eight months ago.

“Ortiz is a well-trained boxer,” Lomachenko said. “He exhibits skills from the amateur school. He’s agile, he has good timing and I expect this to be an interesting fight.”

The 34-year-old Lomachenko will end a 10½-month layoff when he goes up against Ortiz. The two-time Olympic gold medalist has not fought since December 11, in large part due to his involvement in his home country’s war with Russia.

Lomachenko defeated former IBF lightweight champ Richard Commey convincingly in his last fight, which took place two months before the war in Ukraine began. The highly skilled southpaw conquered Commey (30-4-1, 27 KOs) by lopsided scores of 119-108, 119-108 and 117-110 in a 12-round main event ESPN broadcast from Madison Square Garden.

The 26-year-old Ortiz out-pointed Herring (23-4, 11 KOs) by margins of 97-93, 97-93 and 96-94 and legitimized himself as a lightweight contender five months ago.

Keith Idec is a senior writer/columnist for BoxingScene.com. He can be reached on Twitter @Idecboxing.