Anthony Joshua wants to make the biggest statement possible on Saturday night.

Joshua will make his United States debut, when he defends his WBA, IBF, WBO, IBO heavyweight titles against Andy Ruiz at Madison Square Garden in New York City.

Joshua has knocked out 21 of his 22 opponents, with only Joseph Parker going the distance last March in their unification clash.

Two weeks ago, Joshua's main rival - WBC champion Deontay Wilder - scored a brutal first round knockout over mandatory challenger Dominic Breazeale.

And now Joshua wants to answer back with one of his own.

"I want a knockout, heavyweight boxing is about knockouts," Joshua said to Gareth Davies of The Telegraph. "I always want to do that for the fans, but the bottom line is to get a win, however it comes.

"I’ve got to prove myself in America because I don’t think they will come out and accept you easily. If you want to be respected out here, you’ve got be the real deal. They’ve had the best champions flying their flag, so I’ve got to stamp my name in the American books. But I get a really good reception. They embrace the English, that’s for sure."

Ruiz has never been down or seriously hurt as a pro. His only defeat was a close points loss to Joseph Parker back in December of 2017.

Joshua will use the energy of the fans, and the history setting of MSG, to boost his energy level in the ring.

"It’s a good venue. I want to draw on the history. When I went to watch the Saul "Canelo" Alvarez fight [in December 2018, against Liverpudlian Rocky Fielding], it’s so loud in there," said Joshua. "There’s not a bad seat in the house and this is the moment to post my name through the letter box alongside all those great singers, entertainers and fighters who have performed there. It’s a really good feeling," Joshua said.