Undefeated Briton Anthony Joshua is the overwhelming favourite and will have home advantage in the Principality Stadium, although New Zealander Joseph Parker is also unbeaten in his 24 fights and brings with him the WBO belt.
A crowd of 80,000 is expected and Joshua says Parker will have never heard anything like the noise that will be generated.
"It took me a few times to get used to it," Joshua, who has a 20-0 record, told the BBC.
"It's an experience he hasn't faced yet. It is daunting, it is overwhelming. You have a fighter that will block out the noise, which takes a whole heap of energy.
"Then you have a fighter who rides the wave, which can leave you too excited. The fight is won or lost in training camp but the last bolt is screwed on during the spell from your changing room to the first bell."
Whoever wins will become a three-belt heavyweight champion and Joshua says the high stakes will create an electric atmosphere in the Welsh capital.
"This is history," Joshua said. "This is a unification fight with two heavyweights undefeated and it's in the UK.
"Twenty times out of 20 I've been victorious, so expect the same routine."
Parker's promoter David Higgins said Joshua is rattled and warned that Tuesday's pre-fight news conference will start without Joshua if he arrives late, as he has done in the past.
"He's rattled and the press conference tomorrow is all part of that," he told Sky Sports.
"We will be in control of that press conference."
Also scheduled for this card, heavyweights Alexander Povetkin and Davis Price will collide, former world champion Anthony Crolla will faces Edson Ramirez. Crolla is back in action following his win over three-weight king Ricky Burns in Manchester in October.
Ryan Burnett defends his WBA World Bantamweight crown against Yonfrez Parejo, Josh Kelly also goes for his first belt against former IBF World champion Carlos Molina for the WBA International Welterweight title and Welshman Joe Cordina fights for his first pro title with the WBA International Lightweight belt on the line against Andy Townend.


