Mayweather's IV injection (Master thread)

[Spacey1991]

Even floyd fans admit they have zero to none interest in that fight, do you? LOL

I'm not buzzing for it (I keep forgetting that the fights today haha) but I'm going to watch it, mainly because I live in the UK and its on Boxnation so I'm going round my mates house to watch it, the undercard looks decent and I'm looking forward to the Groves fight, funnily enough it's more intriguing than the main event lol.

I can see the PPV flopping tbh, I can't see many people paying $70 to see it.

[.!WAR MIKEY!.]

IV's Come OUt and PLAY!

[Calabis]

Just waiting for the other shoe to drop.

PRP not illegal and just like ivs many athletes do it


Background: Platelet-rich plasma (PRP) is an autologous blood product used to treat acute and chronic tendon, ligament, and muscle injuries in over 86,000 athletes in the United States annually. The World Anti-Doping Agency (WADA) banned intramuscular PRP injections in competitive athletes in 2010 because of concerns that it may increase performance-enhancing growth factors. The ban on PRP was removed in 2011 because of limited evidence for a systemic ergogenic effect of PRP, but the growth factors within PRP remain prohibited.

Purpose: To quantify the effect of PRP injection on systemic growth factors with performance-enhancing effects and to identify molecular markers to detect treated athletes.

Study Design: Descriptive laboratory study.
Methods: Six ergogenic growth factors monitored by WADA—human growth hormone (hGH), insulin-like growth factor–1 (IGF-1), insulin-like growth factor binding protein–3 (IGFBP-3), basic fibroblast growth factor (bFGF or FGF-2), vascular endothelial growth factor (VEGF), and platelet-derived growth factor–BB (PDGF-BB)—were measured in 25 patients before (baseline) and at 0.25, 3, 24, 48, 72, and 96 hours after intratendinous leukocyte-rich PRP injection. Eating and exercise were prohibited for 3 hours before testing. Growth factors were quantified by enzyme-linked immunosorbent assay, and the change relative to each patient’s baseline was calculated.

Results: Relative to serum, PRP contained significantly more bFGF (226 vs 5 pg/mL), VEGF (1426 vs 236 pg/mL), and PDGF-BB (26,285 vs 392 pg/mL), but IGF-1 and hGH were not elevated. Serum levels increased significantly for IGF-1 at 24 and 48 hours, for bFGF at 72 and 96 hours, and for VEGF at 3, 24, 48, 72, and 96 hours after PRP injection. Additionally, VEGF was increased in all 25 patients after PRP treatment.

Conclusion: Serum IGF-1, VEGF, and bFGF levels are significantly elevated after PRP injection, supporting a possible ergogenic effect of PRP. An indirect marker for hGH doping, the product of IGFBP-3 × IGF-1, also significantly increased after PRP. Platelet-rich plasma appears to trigger an increase in circulating growth factors through activating biological pathways rather than by serving as a vehicle for the direct delivery of presynthesized growth factors. Elevated VEGF was observed in all patients after PRP, and ***8805;88% of patients had elevated VEGF at each time point from 3 to 96 hours after PRP, suggesting that VEGF may be a sensitive molecular marker to detect athletes recently treated with PRP.

Clinical Relevance: This is the first and only adequately powered study of the systemic effects of PRP. We present evidence that PRP contains and may trigger systemic increases in substances currently banned in competitive athletes.Finally, we provide evidence that VEGF could serve as a useful molecular marker to detect athletes treated with PRP.

[BrometheusBob.]

Dam this turned int May/Pac master thread all over again. Except this time the side with a leg to stand on has turned.

[BrometheusBob.]

Floyd was given a TUE which makes the amounts irrelevant. Worthy of su****ion? Sure. Smoking gun? Not so much.

No except it doesn't. USADA's own rules clearly require prior approval of a TUE and have specific instructions on what that must be for - rehydration is not one of those things. The retroactive exemption only proves USADA is full of **** and will bend the rules when they see fit.

[BrometheusBob.]

At least now we know what happened to Pacquiao's confiscated Water and Vitamins. They were in Mayweathers IV.

They don't play around with saltwater and vitamins, unless it's being pushed directly into Mayweather's veins right before a drug test... then it's all good.

Two days ago. Four months to gather evidence and make their case. They drop the "bomb" and a day later nobody is talking about it anymore except angry pac fans. Yeah, sure sounds like Floyd got exposed big time .

Who exactly needs to be talking about it for you guys to not think it's nobody? More news coverage came for this than Pacquiao's "miraculous recovery".

[stormfroe]

Dam this turned int May/Pac master thread all over again. Except this time the side with a leg to stand on has turned.

and floyd vs berto is happening today ! :lol: which means this sites gonna go crazier with post fight issues like PPV buys etc. etc.

[IR0NFIST]

PRP not illegal and just like ivs many athletes do it


Background: Platelet-rich plasma (PRP) is an autologous blood product used to treat acute and chronic tendon, ligament, and muscle injuries in over 86,000 athletes in the United States annually. The World Anti-Doping Agency (WADA) banned intramuscular PRP injections in competitive athletes in 2010 because of concerns that it may increase performance-enhancing growth factors. The ban on PRP was removed in 2011 because of limited evidence for a systemic ergogenic effect of PRP, but the growth factors within PRP remain prohibited.

Purpose: To quantify the effect of PRP injection on systemic growth factors with performance-enhancing effects and to identify molecular markers to detect treated athletes.

Study Design: Descriptive laboratory study.
Methods: Six ergogenic growth factors monitored by WADA—human growth hormone (hGH), insulin-like growth factor–1 (IGF-1), insulin-like growth factor binding protein–3 (IGFBP-3), basic fibroblast growth factor (bFGF or FGF-2), vascular endothelial growth factor (VEGF), and platelet-derived growth factor–BB (PDGF-BB)—were measured in 25 patients before (baseline) and at 0.25, 3, 24, 48, 72, and 96 hours after intratendinous leukocyte-rich PRP injection. Eating and exercise were prohibited for 3 hours before testing. Growth factors were quantified by enzyme-linked immunosorbent assay, and the change relative to each patient’s baseline was calculated.

Results: Relative to serum, PRP contained significantly more bFGF (226 vs 5 pg/mL), VEGF (1426 vs 236 pg/mL), and PDGF-BB (26,285 vs 392 pg/mL), but IGF-1 and hGH were not elevated. Serum levels increased significantly for IGF-1 at 24 and 48 hours, for bFGF at 72 and 96 hours, and for VEGF at 3, 24, 48, 72, and 96 hours after PRP injection. Additionally, VEGF was increased in all 25 patients after PRP treatment.

Conclusion: Serum IGF-1, VEGF, and bFGF levels are significantly elevated after PRP injection, supporting a possible ergogenic effect of PRP. An indirect marker for hGH doping, the product of IGFBP-3 × IGF-1, also significantly increased after PRP. Platelet-rich plasma appears to trigger an increase in circulating growth factors through activating biological pathways rather than by serving as a vehicle for the direct delivery of presynthesized growth factors. Elevated VEGF was observed in all patients after PRP, and ***8805;88% of patients had elevated VEGF at each time point from 3 to 96 hours after PRP, suggesting that VEGF may be a sensitive molecular marker to detect athletes recently treated with PRP.

Clinical Relevance: This is the first and only adequately powered study of the systemic effects of PRP. We present evidence that PRP contains and may trigger systemic increases in substances currently banned in competitive athletes.Finally, we provide evidence that VEGF could serve as a useful molecular marker to detect athletes treated with PRP.

"The growth factors within PRP remain prohibited. PRP contains and may trigger systemic increases in substances currently banned in competitive athletes."

Floyd is looking for every possible advantage he can get. All he wants is an even playing field, yet he plants spies in his opponents camp and takes banned IVs containing 15 times the legal amount of saline to mask PED use.

[URAGONAKO]

So Floyd drove 10+ miles from MGM to his home to have the IV, isn't it there's a nearby hospital in Flamingo Rd like less than a mile away from MGM?

Why does Floyd had an IV in his home? Where they already anticipated that Floyd would be dehydrated? Why not bring the IV in the MGM in the first place?

[BrometheusBob.]

and floyd vs berto is happening today ! :lol: which means this sites gonna go crazier with post fight issues like PPV buys etc. etc.

Hm didn't think of that. No end of the May/Pac discussion in sight.