I don't think it's that, Personally I think Pacquiao is open to the right straight. Not as open as he used to be like the first Marquez fight as he obviously can defend it better now but if you watch the fights against Marquez I and II and Clottey whenever he was hit it was the right hand.
Cotto is a converted southpaw (southpaw that fights from an orthadox stance) which is why his jab is so powerful and his right hand isn't so he couldn't take advantage of that. Margarito doesn't have a great straight right and Clottey can't do both offence and defence at the same time. Mayweather would trouble Pacquiao with the right hand all night long
However, I also think Mayweathers defence is more open to southpaws (Judah uses the same defence but since he's a southpaw Orthadox fighters can get around it) it's a double edged sword.
To me that and the jab go hand in hand, the jab would only make the straight right more effective as long as Mayweather is throwing the jab with proper range and authority.
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