No but he will still generate big money because he has a loyal nationalistic fanbase and the backing of the wealthiest man in the world, unless he loses another 12-0 shutout which might make fans turn away.
Losing to Floyd and Cotto, if he loses, isn't a negative.
Losing to Floyd and Cotto is hardly career ending. It does, however, depend on the manner of the defeat. If he gets sparked out in the first, it would definitely kill some hype, but if he lost a close decision he'd probably be fine.