Mosley has been hurt before, Vernon Forrest knocked him down in their first fight, i think it was an uppercut that put him down. I pick Margarito to TKO Mosley in the 9th or 10th.
I going to go ahead and say that this is a toss up. It was eaaasssy to pick marg against Cotto because I had seen cotto hurt and wobbled by nobodys countless times, but I cant recall ever seeing Shane hurt. Margs style of koing people or breaking their will might not work as well against shane.