Anthony Mundine's boxing career has hit the end of the road, after the former WBA super middleweight champion lost in a shocker to John Wayne Parr in Brisbane.

Judges scored the fight 95-94 for Mundine, and 96-93 and 95-93 in favor of the Muay Thai legend who was fighting in a boxing ring for the first time in 16 years.

Mundine was knocked down in the fourth round of the middleweight contest but survived a standing eight count before being docked a point in the eighth for hitting Parr in the back of the head.