According to promoter Eddie Hearn, heavyweights Deontay Wilder and Tyson Fury are likely steaming after the WBC's recent order.
The World Boxing Council officially sanctioned Saturday's fight, between Dillian Whyte and Oscar Rivas, for the vacant interim-title.
That means the winner will become the mandatory challenger to Wilder's WBC world title.
The winner of Whyte-Rivas will surely cause some turmoil in the plans of Wilder and Fury - who are planning to stage a rematch in the early part of 2020.
Wilder will first likely face Luis Ortiz in a rematch later this year, and Fury is planning to fight in the fall as well.
And the winner of Wilder-Fury will be forced to face Whyte next.
"I don't think they're very happy and they'll try everything they can to try and get out of it, but now we have it solid," Hearn told Sky Sports.
"He's wanted Wilder for a long, long time. Fury called him out recently and we have publicly accepted that challenge and he's changed his mind, so I don't think anyone wants to fight Dillian Whyte. That's why we've had to force the mandatory position. It's going to be interesting, but that's again why we had to get this position, because no one is going to choose Dillian Whyte to fight."
If Whyte hands Rivas the first defeat of his career, Hearn is planning to keep him busy in the fall.
"Once the Luis Ortiz fight was allowed, which we knew it would always be allowed, Dillian was going to fight in November-December anyway," said Hearn.
"Dillian always wants a proper fight, but once he's got the guaranteed mandatory shot, my advice would not be to fight (Oleksandr) Usyk or (Alexander) Povetkin, or those kind of guys. I think he'll maybe go to the States, and have a fight, and get ready for the winner of Wilder-Fury."