I picked Floyd but I don't think he pot shots and UDs. Khan is fast but now that I saw the systematic beating he gave Mosley. I see Floyd being un affected by speed. Mayweather is very accurate with his punches and sooner or later, one of those might hurt Khan's questionable chin...
If Khan can beat Maidana and then Bradley, I would give him a fair shot at beating Mayweather. Khan has a great jab, great speed, great stamina, a good defence, decent power, and throws a lot of punches. He would be a tough fight for Floyd that's for sure.
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