Commonwealth light-heavyweight champion Tony Bellew will make the first defence of his title on Frank Warren's annual charity card.
This year's DebRA show will take place on September 24 at the Grosvenor House Hotel in London.
Previous events have helped raise hundreds of thousands of pounds for DebRA.
It is the national charity working on behalf of people in the UK with the genetic skin blistering condition Epidermolysis Bullosa (EB).
Now in it's fifth year, the black tie dinner is always a sell out, and attended by celebrities as well as as some of boxing's biggest names.
"It's an honour to be headlining a card for such a worthwhile charity," said Bellew, who will put his title on the line against Bob Ajisafe.
"I fought on the card last year and was very moved by some of the tragic stories I heard that night.
"I can't wait to put on a good show for everyone there, and help raise money for what is an excellent cause."
The Bomber, unbeaten now in 13 fights, lifted his title with a first round KO in his last fight.
And now Nathan Cleverly is poised to fight for the interim WBO light-heavyweight title, he is eyeing the Welshman's British and European crowns, which could become vacant.
"Everyone keeps talking about me against Nathan," said heavy-handed Bellew, who has drawn comparisons to fellow scouser John Conten.
"Nathan wants the fight, I want the fight and Frank Warren wants the fight, so it's bound to happen.
"When it does there are going to be fireworks, but I'm going to knock him out because no one can deal with my power."
