There was a possibility that Khan would make his comeback on the Oscar De La Hoya-Manny Pacquiao undercard in Las Vegas on the same night, but Khan's return will now be in Britain.
The 21-year-old from Bolton is working with new trainer Freddie Roach at his Wild Cards Gym in Los Angeles, and will remain in the US until a couple of weeks before the fight when he returns to Britain to finish off his training.
However, Roach will not be in Khan's corner on the night due to his commitment to work with Pacquiao, instead Dean Powell - who trained Khan for his win over Michael Gomez in June - will be in his place.
Warren said, "I'm delighted to confirm that Amir will make his long-awaited return at the ExCeL on December 6. It's all set to be a fantastic show for the fans in the capital featuring Britain's only world champion Nicky Cook who makes the first defence of his title on his home patch, a make or break fight for Audley Harrison against Martin Rogan, all-action Anthony Small defends his title, plus an action packed undercard featuring out best talented prospects."
Warren also added that there will be one more big title fight to be added to the card and further details will be announced at a press conference in London on Thursday (30 October) at a venue to be confirmed.
***FIGHT CARD***
FRANK WARREN PROUDLY PRESENTS
WORLD CHAMPIONSHIP BOXING
SATURDAY, DECEMBER 6, 2008
ExCeL LONDON
TICKET MASTER: 0844 847 2500
SEE TICKETS: 0871 220 0260
FRANK WARREN: 01992 550 888
THE WBO SUPER-FEATHERWEIGHT CHAMPIONSHIP OF THE WORLD
Nicky Cook (Dagenham, England) vs. TBA
LIGHTWEIGHT CHAMPIONSHIP (TBA)
Amir Khan (Bolton, England) vs. TBA
10 X 3 Minute Rounds Heavyweight Contest
Audley Harrison (Park Royal, London, England) vs. Martin Rogan (Northern Ireland)
THE WBA INTERCONTINENTAL LIGHT-MIDDLEWEIGHT CHAMPIONSHIP
Anthony Small (Deptford, London, England) vs. TBA
10 X 3 Minute Rounds International Middleweight Contest
Paul Smith (Liverpool, England) vs. TBA
8 X 3 Minute Rounds Heavyweight Contest
Derek Chisora (Finchley, London, England) vs. TBA
6 X 3 Minute Rounds Light-Welterweight Contest
Jamie Cox (Swindon, England) vs. TBA
4 X 3 Minute Rounds Featherweight Contest
Liam Walsh (Cromer, England) vs. TBA
4 X 3 Minute Rounds Super-Flyweight Contest
Michael Walsh (Cromer, England) vs. TBA
4 X 3 Minute Rounds Featherweight Contest
Ryan Walsh (Cromer, England) vs. TBA
***ONE FURTHER CHAMPIONSHIP TITLE FIGHT TO BE ADDED***