The talented Scotsman will challenge for the WBO Intercontinental super-featherweight title at the Braehead Arena, Glasgow, live on Sky Sports 1HD.
And he's hoping victory will put him on the path for an all-Scottish blockbuster world title clash with Ricky Burns.
A win could see the 23-year-old enter the WBO's top 15.
Appleby will take on Ghana's Joseph Laryea over 12 rounds, his first fight at the distance since losing his British title against Martin Lindsay.
"It's great to be back in title contention," said Appleby, a former Boxing Writers' Young Boxer of the Year award winner.
"I've felt fantastic in my last two fights, and now it's time to step up to the next level.
"I'm not taking Laryea at all lightly because these fighters from Africa are always dangerous.
"I watched Liam Walsh's fight against Maxwell Awuku a couple of weeks ago, and he was given everything he could handle.
"I'm hoping that Laryea comes to fight because I want to prove that I am one of the best super-featherweights in the UK right now.
"I've had a look at his record and it's decent one, and in his last fight he won the Ghanaian super-featherweight title, so he's no mug."
Tickets for Monarch of the Glen, priced at £50, £75 and £100, are available from:
Braehead Arena
0844 499 1700
www.braehead-arena.co.uk
Ticket Master
0844 844 0444
www.ticketmaster.co.uk
See Tickets
0871 620 7054
www.seetickets.com