Clenbuterol, fed for 1 wk, increased the wet weight of the gastrocnemius, soleus, and extensor digitorum longus muscles (15-23%) in both normal and D + I ****. Although clenbuterol increased body weight gain, it did not alter feed consumption and, therefore, feed efficiency (g gain/g food) was improved. Activities of cathepsin B and N-acetyl-beta-glucosaminidase, but not cathepsin D, were elevated in the soleus muscles of clenbuterol-treated ****. The clenbuterol-induced increase in muscle growth in the insulin-replaced diabetic **** indicated that this beta-adrenergic agonist effect was not mediated by an alteration of circulating levels of insulin, secondary to beta-agonist action on pancreatic insulin release.
Clenbuterol treatment increased the weight of skeletal muscles 22% to 39% in 3-month-old ****, 19% to 35% in 12-month-old ****, and 22% to 25% in 23-month-old animals. Likewise, clenbuterol increased carcass protein content 19% in 3-month-old ****, 16% in 12-month-old ****, and 24% in 23-month-old animals. Conversely, the drug reduced carcass fat content 36% in 3-month-old ****, 32% in 12-month-old ****, and 38% in 23-month-old ****. Therefore, clenbuterol had similar anabolic and catabolic effects in all age groups. In addition, clenbuterol stimulated recovery of skeletal muscle protein lost following pump implantation in senescent ****.
Clenbuterol is not only used to burn fat, it's used to generate muscle mass as well. It has both effects.
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