Bookmark Website  | Free Registration  | The Team
The Lounge  | Champions  | The Wire |  Schedule |  Audio  |  Arcade  |  The Top Ten  |  Historical  |  Email  |  Video

Safe and Permanent Weight Loss Cannot Be Achieved in the Fed State


Weight Loss Axiom Number Three

Insulin and Glucagon

These are the two major hormones that control energy metabolism in the human. They are much like yin andyang, hot and cold or happy and sad. In order to really enjoy the good days, we all have bad days. Extremes of eithertoo hot or too cold and soon everyone complains about the weather. Too much yin or too much yang and according to traditional Chinese Medicine, you are sick. Too much insulinand you are sick, hypertension, overweight, cancer, heart disease and stroke. Too much glucagon and you are toothin, emaciated and weak.

As we have mentioned previously, when man evolved there wouldbe times of famine, between times of feast. The biochemistry of this evolution allowed man to survive the periods of famineby using insulin to "store" energy. Some typical "fuel" reserves in a 70 kilogram man:

Organ ***************** Available energy (kcal)
************ glucose/glycogen ***** fat ***** protein
blood *********** 60 ************** 45 ********* 0
liver *********** 400 ************* 450 ******** 400
brain *********** 8 *************** 0 ********** 0
muscle ********** 1200 ************ 450 ******** 24000
adipose(fat) **** 80 ************** 135,000 **** 40

from Stryer Biochemistry 4th Edition page 771

Look at the chart and find the biggest number. The largestamount of available energy in an average 70 kilogramhuman is overwhelmingly stored in -fat. For the purpose ofthis discussion let's think of each of these numbers aboveas fuel tanks, for our energy needs. When we fill up ourcars with gasoline (our old Mercedes B100 biodiesel) we haveto have a fuel hose to get the fuel into our gas tank. Inorder to use that fuel in our gas tanks, we have to have afuel line leading from the gas tank to the motor in ourcar. Without these fuel lines, we could not utilize ourengine / car.

Enzymatic Induction

Human biochemistry is composed of many different enzyme systems.One such enzyme is phosphofructokinase that catalyzes the reaction of fructose 6-phosphate to fructose 1,6-bisphosphate.As with any biochemical reaction that is dependant on anenzyme system, the more it is used, the more developed itbecomes. If there is no need for an enzyme, then the levelsin the body will be very low. If there is much demand for an enzyme, then the body will synthesize more of it to meetthe demands.

Filling your tank with gas

The fuel line for the human body to fill its energy storagetanks, especially the largest energy storage tank fat, isinsulin. Insulin is the hose that energy (gasoline, biodiesel)flows from the storage tank (breakdown products of your recently ingested meals) into your gas tank for future use.Without this fuel line insulin, you will eventually go intoa coma (hyperosmolar) that if not treated, can result in lessthan optimal outcomes.

Using the gas in your tank

When we drive our cars, we use the energy stored in the fueltanks. In order for us to use that fuel, it must get fromthe storage tank to the motor. In the human, that fuel lineis glucagon. Remember, insulin stores energy, glucagonutilizes that stored energy. Just as insulin stimulates energy storage and the necessary enzyme systems, glucagonstimulates energy utilization and the necessary enzyme systems required to accomplish this.

Life in the Fed State

The problem today is that we have evolved from creatures thatdid not have consistent daily feedings to our "modern" fastfood insanity and the notion that now we need three "square"meals a day plus snacks. What happens to our energy metabolismwhen we start out putting insulin stimulating foods in ourstomach three times a day? When we eat, our biochemistryreacts by secreting insulin, so that we can store all thisenergy for future needs -most of it going into fat. Longbefore we have used any of this energy, we are having anothermeal -lunch. More gas in our tanks, -none used yet. Then comes dinner -more gas into our tank. Snacks -more gas in.We spend our whole day and most of the night in a "fed" orinsulin state.

Huge fuel tanks full of fat -everywhere

Because we never allow our body's insulin level to drop enoughso that the glucagon level will rise, we never get into a "glucagon" state. Our whole car is now filled mostly withgas. There is hardly any room for a driver in the front seat.Huge fuel tanks full of fat are everywhere we look. Yourcar is loaded with gas, but you can't drive around the blockbecause you haven't developed the enzymes of energy utilizationto establish a fuel line between all these gas tanks fullof fat and our motor, which is now also encased in fat.While insulin is the fuel line to fill our energy stores, glucagon is the fuel line to use this stored energy. Withoutproper stimulation of the glucagon system, our tanks justkeep filling up with fat. We never develop the necessaryenzymes to use all this energy. You don't have to travel toofar to see people totally encased in their stored energy.

Livin' la vida de glucagon

To break this cycle, we need to stop eating for at least a portion of the day, or at least every other day. I don't knowhow many of you have ever fasted for 24 hours or more, but the feeling is incredible. You get a lot more work done,you don't get lethargic after eating and you start to actuallyfeel thin. I don't recommend fasting more than 24 hoursand I am not actually recommending a 24 hour fast. What Iam recommending is that during some portion of every day orat least every other day, you refrain from eating anythingso that you can get into a glucagon state and begin to inducethe necessary enzymes to use all the energy the human bodycan store.

Summary

Like it or not, three meals a day plus snacks is just not healthy.

Copyright © John Mericle M.D. 2005 All Rights Reserved

To sign up for Dr. Mericle's Newsletter or visit the MericleDiet please click on the link below.

http://www.DrMericle.com

DrMericle.com is devoted to achieving optimal health and peak performance through diet and lifestyle change. Dr. Mericle brings together a unique blend of formal training in organic chemistry and biochemistry, medical education, 29 marathons, 3 Hawaii Ironman competitions and a lot of practical real life experience.


MORE RESOURCES:

DailyFinance

FTC Bans Diet Pill Seller from the Weight-Loss Business
DailyFinance
Weight Loss. kurhan/Shutterstock The maker of a line of diet supplements sold at the nation's largest pharmacies with the false promise that the pills would magically make users slender (they didn't) was banned -- at least, for now -- from selling ...
FTC Approves Final Orders Banning Marketer Behind 'Fat Burner' Diet Pills From ...Yumanewsnow

all 2 news articles »


The Inquisitr

Permanent Weight Loss Adds Years To Life - Proven Ways To Help Take It Off ...
The Inquisitr
The Center for Disease Control (CDC) claims that healthy weight loss is not a diet – it is a lifestyle. Setting a realistic goal – such as losing one to two pounds per week – is critical to a successful weight loss program. Crash diets don't seem to ...



Weight-Loss Superfood: 6 Tips for a Healthy Gut
Live Science
Over the years, I've noticed that clients who added a certain item to their diet seemed more likely to lose weight. And this happened even when their calorie intake remained the same. What is this superfood? It's nothing weird, and it's not a ...

and more »


Long-term Effects of Rapid Weight Loss vs. Gradual Weight Loss
Diabetes In Control
Most of the guidelines suggest that patients should lose weight gradually as opposed to rapidly losing weight, indicating that patients who had rapid weight loss are more likely to regain the weight. This study looked at effect of the rate of weight ...



TheHealthSite

Scientists discover how our body regulates weight loss
TheHealthSite
Weight loss is a constant concern for many and scientists too are on a lookout to find out ways can help us do so. A hormone seen as a popular target to develop weight loss drugs works by directly targeting the brain and triggering previously unknown ...
Weight Loss Hormone Activates Brain Pathways That Instruct Body To Burn Fat ...Medical Daily
How body regulates weight lossZee News
Scientists discover new clues to how weight loss is regulatedHealthCanal.com
EurekAlert (press release)
all 17 news articles »


IRS raids Fairway home of weight-loss surgeon
KCTV Kansas City
Billie Lovell paid $11,000 for weight-loss surgery at Malley's Mission office in August. β€œIt was for the surgery, the hospital bill and for a year's follow up,” Lovell explained. But the day she was scheduled for follow up, her doctor's office closed ...



NPR (blog)

Banned Drugs Still Turning Up In Weight-Loss Supplements
NPR (blog)
Americans spend about $4 billion a year on weight-loss supplements. And the Food and Drug Administration spends a lot of effort policing distributors who market fraudulent products that are tainted with unsafe, banned drugs. But a study published ...

and more »


Huffington Post

What If It Wasn't About Weight Loss
Huffington Post
Belief 1: A workout automatically means weight loss. We've all heard the sayings "sweating for the wedding" and "a funeral for my fat," plus most of the "fitspiration" out there has to do with one thing only: looking a certain way. Belief 2. We diet to ...

and more »


Rick Kupchella's BringMeTheNews

New study re-examines gradual vs. rapid weight loss
Rick Kupchella's BringMeTheNews
In recent years, the prevailing wisdom about maintaining weight loss has been that a slower, steadier approach to dropping pounds is the best way to keep that weight off. But now a new study published in The Lancet Diabetes and Endocrinology is ...
For Lasting Weight Loss, Go Fast or Slow?Huffington Post Canada

all 7 news articles »


Rochester Democrat and Chronicle (blog)

Fun Sized: The F-word in Weight Loss
Rochester Democrat and Chronicle (blog)
Fleet Feet Sports' Ton of Fun Weight Loss Challenge is heading into the latter half of the 12 week challenge. This is not an easy session, while the first half provides us with the start of school and the beginning of fall which can help provide some ...


Google News


Advertisement



Section Site Map - Submit News - Feedback - Comments - Advertise with Us

Copyright © 2006 Luminati Inc. All rights reserved.