Bookmark Website  | Free Registration  | The Team
The Lounge  | Champions  | The Wire |  Schedule |  Audio  |  Arcade  |  The Top Ten  |  Historical  |  Email  |  Video

Safe and Permanent Weight Loss Cannot Be Achieved in the Fed State


Weight Loss Axiom Number Three

Insulin and Glucagon

These are the two major hormones that control energy metabolism in the human. They are much like yin andyang, hot and cold or happy and sad. In order to really enjoy the good days, we all have bad days. Extremes of eithertoo hot or too cold and soon everyone complains about the weather. Too much yin or too much yang and according to traditional Chinese Medicine, you are sick. Too much insulinand you are sick, hypertension, overweight, cancer, heart disease and stroke. Too much glucagon and you are toothin, emaciated and weak.

As we have mentioned previously, when man evolved there wouldbe times of famine, between times of feast. The biochemistry of this evolution allowed man to survive the periods of famineby using insulin to "store" energy. Some typical "fuel" reserves in a 70 kilogram man:

Organ ***************** Available energy (kcal)
************ glucose/glycogen ***** fat ***** protein
blood *********** 60 ************** 45 ********* 0
liver *********** 400 ************* 450 ******** 400
brain *********** 8 *************** 0 ********** 0
muscle ********** 1200 ************ 450 ******** 24000
adipose(fat) **** 80 ************** 135,000 **** 40

from Stryer Biochemistry 4th Edition page 771

Look at the chart and find the biggest number. The largestamount of available energy in an average 70 kilogramhuman is overwhelmingly stored in -fat. For the purpose ofthis discussion let's think of each of these numbers aboveas fuel tanks, for our energy needs. When we fill up ourcars with gasoline (our old Mercedes B100 biodiesel) we haveto have a fuel hose to get the fuel into our gas tank. Inorder to use that fuel in our gas tanks, we have to have afuel line leading from the gas tank to the motor in ourcar. Without these fuel lines, we could not utilize ourengine / car.

Enzymatic Induction

Human biochemistry is composed of many different enzyme systems.One such enzyme is phosphofructokinase that catalyzes the reaction of fructose 6-phosphate to fructose 1,6-bisphosphate.As with any biochemical reaction that is dependant on anenzyme system, the more it is used, the more developed itbecomes. If there is no need for an enzyme, then the levelsin the body will be very low. If there is much demand for an enzyme, then the body will synthesize more of it to meetthe demands.

Filling your tank with gas

The fuel line for the human body to fill its energy storagetanks, especially the largest energy storage tank fat, isinsulin. Insulin is the hose that energy (gasoline, biodiesel)flows from the storage tank (breakdown products of your recently ingested meals) into your gas tank for future use.Without this fuel line insulin, you will eventually go intoa coma (hyperosmolar) that if not treated, can result in lessthan optimal outcomes.

Using the gas in your tank

When we drive our cars, we use the energy stored in the fueltanks. In order for us to use that fuel, it must get fromthe storage tank to the motor. In the human, that fuel lineis glucagon. Remember, insulin stores energy, glucagonutilizes that stored energy. Just as insulin stimulates energy storage and the necessary enzyme systems, glucagonstimulates energy utilization and the necessary enzyme systems required to accomplish this.

Life in the Fed State

The problem today is that we have evolved from creatures thatdid not have consistent daily feedings to our "modern" fastfood insanity and the notion that now we need three "square"meals a day plus snacks. What happens to our energy metabolismwhen we start out putting insulin stimulating foods in ourstomach three times a day? When we eat, our biochemistryreacts by secreting insulin, so that we can store all thisenergy for future needs -most of it going into fat. Longbefore we have used any of this energy, we are having anothermeal -lunch. More gas in our tanks, -none used yet. Then comes dinner -more gas into our tank. Snacks -more gas in.We spend our whole day and most of the night in a "fed" orinsulin state.

Huge fuel tanks full of fat -everywhere

Because we never allow our body's insulin level to drop enoughso that the glucagon level will rise, we never get into a "glucagon" state. Our whole car is now filled mostly withgas. There is hardly any room for a driver in the front seat.Huge fuel tanks full of fat are everywhere we look. Yourcar is loaded with gas, but you can't drive around the blockbecause you haven't developed the enzymes of energy utilizationto establish a fuel line between all these gas tanks fullof fat and our motor, which is now also encased in fat.While insulin is the fuel line to fill our energy stores, glucagon is the fuel line to use this stored energy. Withoutproper stimulation of the glucagon system, our tanks justkeep filling up with fat. We never develop the necessaryenzymes to use all this energy. You don't have to travel toofar to see people totally encased in their stored energy.

Livin' la vida de glucagon

To break this cycle, we need to stop eating for at least a portion of the day, or at least every other day. I don't knowhow many of you have ever fasted for 24 hours or more, but the feeling is incredible. You get a lot more work done,you don't get lethargic after eating and you start to actuallyfeel thin. I don't recommend fasting more than 24 hoursand I am not actually recommending a 24 hour fast. What Iam recommending is that during some portion of every day orat least every other day, you refrain from eating anythingso that you can get into a glucagon state and begin to inducethe necessary enzymes to use all the energy the human bodycan store.

Summary

Like it or not, three meals a day plus snacks is just not healthy.

Copyright © John Mericle M.D. 2005 All Rights Reserved

To sign up for Dr. Mericle's Newsletter or visit the MericleDiet please click on the link below.

http://www.DrMericle.com

DrMericle.com is devoted to achieving optimal health and peak performance through diet and lifestyle change. Dr. Mericle brings together a unique blend of formal training in organic chemistry and biochemistry, medical education, 29 marathons, 3 Hawaii Ironman competitions and a lot of practical real life experience.


MORE RESOURCES:

CNN

Woman ditches diets, loses 160 pounds
CNN
(CNN) -- Teena Henson's "journey to life" began with a newspaper ad. She remembers wishing they had an Anytime Fitness in her hometown of Gilmer, Texas. She specifically wanted to join Anytime Fitness because it is open 24/7 and is made for men and ...
Teena Henson: the Wonder Woman of Weight LossYottaFire
Weight loss without diets possible!Delhi Daily News
Why Diets Often Fail (Video)The Epoch Times
wtvr.com
all 34 news articles »


Examiner.com

Dr. Oz busts weight-loss & diet myths: You don't need to exercise to lose weight
Examiner.com
Dr. Mehmet Oz dispelled common diet myths that could sabotage weight loss on the April 21 episode of the "Dr. Oz Show." Dr. Oz's guest was obesity expert Dr. Joel Fuhrman, who said the wrong beliefs about dieting are what make it hard for some people ...
The Dr. Oz Show Recap: Small Meals & Exercise For Weight Loss Are Diet Lies ...Nerdles
Dr. Oz Show Today April 21: Biggest Diet Lies Keeping You FatCMR

all 4 news articles »


Sportsplex weight-loss contest has Born winner
SouthtownStar
The recent Weight Loss Challenge at the Orland Park Sportsplex boasted a Born winner. Literally. Mary Ellen Born is the 2014 winner and collected $500 for losing 26 pounds — 13.83 percent of her total body weight — according to a press release from ...



Annie's Mailbox: Weight-loss surgery a drastic measure
The Spokesman Review
Dear Annie: I am quite a bit overweight. My 29-year-old daughter is concerned that I might have a heart attack and die on her. Meanwhile, she has been smoking cigarettes since she was 16 years old. She said to me, “If you have gastric bypass surgery, I ...
Daughter driving hard weight-loss bargainSentinel and Enterprise

all 8 news articles »


Extra

Debbie Gibson Reveals Drastic Weight Loss Caused by Lyme Disease
ABC News (blog)
For as much as most people worry about their bodies and dieting, imagine if all of a sudden you couldn't eat foods that were a regular part of your diet, and as a result, you couldn't stop losing weight? That's what happened to 1980′s pop icon and the ...
Debbie Gibson Blames Extreme Weight Loss on Terrifying Battle with DiseaseExtra

all 57 news articles »


Examiner.com

Kim Kardashian launches extreme low carb ketogenic diet for wedding weight loss
Examiner.com
Kardashian previously credited the Atkins diet for her jaw-dropping 56-pound weight loss, which she achieved just six months after giving birth to daughter North in June 2013. Kim's weight-loss plan was a low-carb, high-fat ketogenic-style diet known ...
Kim Kardashian in Weight Loss Frenzy for 2014 Wedding with Kanye WestNational Ledger

all 224 news articles »


BBB, FTC issue alerts about weight loss supplements
Easton Courier
While some consumers will turn to the gym and others modify their diets, Connecticut Better Business Bureau warns consumers that some weight loss supplements make outrageous claims that you can lose substantial weight over a short period, without ...
Connecticut Better Business Bureau Issues Warning on Weight-Loss SupplementsNatural Products INSIDER

all 3 news articles »


Weight Loss class
Youngstown Vindicator
The YWCA of Youngstown, 25. W. Rayen Ave., is offering “If Scales Could Speak! Weight Loss 101,” a health fair for women, from 9:30 a.m. to 1 p.m. Saturday. April is Minority Health Month in Ohio. The heath fair includes a yoga session and information ...



Weight Loss Drug Acknowledges Struggle
MediaPost Communications
The spot -- which will air on numerous channels including Lifetime, Oxygen and AMC – presents the drug as a targeted approach to weight loss, that, when combined with diet and increased activity, may help some patients lose weight and keep it off.



Who's winning the weight loss challenge?
Asheboro Courier Tribune
ASHEBORO — The inaugural A3 Asheboro Weigh Down Challenge is half way through its 10-week weight loss campaign where nearly 200 individuals and organized teams have lost approximately 900 pounds. Teams include Asheboro City, Asheboro ...


Google News


Advertisement



Section Site Map - Submit News - Feedback - Comments - Advertise with Us

Copyright © 2006 Luminati Inc. All rights reserved.