Bookmark Website  | Free Registration  | The Team
The Lounge  | Champions  | The Wire |  Schedule |  Audio  |  Arcade  |  The Top Ten  |  Historical  |  Email  |  Video

Safe and Permanent Weight Loss Cannot Be Achieved in the Fed State


Weight Loss Axiom Number Three

Insulin and Glucagon

These are the two major hormones that control energy metabolism in the human. They are much like yin andyang, hot and cold or happy and sad. In order to really enjoy the good days, we all have bad days. Extremes of eithertoo hot or too cold and soon everyone complains about the weather. Too much yin or too much yang and according to traditional Chinese Medicine, you are sick. Too much insulinand you are sick, hypertension, overweight, cancer, heart disease and stroke. Too much glucagon and you are toothin, emaciated and weak.

As we have mentioned previously, when man evolved there wouldbe times of famine, between times of feast. The biochemistry of this evolution allowed man to survive the periods of famineby using insulin to "store" energy. Some typical "fuel" reserves in a 70 kilogram man:

Organ ***************** Available energy (kcal)
************ glucose/glycogen ***** fat ***** protein
blood *********** 60 ************** 45 ********* 0
liver *********** 400 ************* 450 ******** 400
brain *********** 8 *************** 0 ********** 0
muscle ********** 1200 ************ 450 ******** 24000
adipose(fat) **** 80 ************** 135,000 **** 40

from Stryer Biochemistry 4th Edition page 771

Look at the chart and find the biggest number. The largestamount of available energy in an average 70 kilogramhuman is overwhelmingly stored in -fat. For the purpose ofthis discussion let's think of each of these numbers aboveas fuel tanks, for our energy needs. When we fill up ourcars with gasoline (our old Mercedes B100 biodiesel) we haveto have a fuel hose to get the fuel into our gas tank. Inorder to use that fuel in our gas tanks, we have to have afuel line leading from the gas tank to the motor in ourcar. Without these fuel lines, we could not utilize ourengine / car.

Enzymatic Induction

Human biochemistry is composed of many different enzyme systems.One such enzyme is phosphofructokinase that catalyzes the reaction of fructose 6-phosphate to fructose 1,6-bisphosphate.As with any biochemical reaction that is dependant on anenzyme system, the more it is used, the more developed itbecomes. If there is no need for an enzyme, then the levelsin the body will be very low. If there is much demand for an enzyme, then the body will synthesize more of it to meetthe demands.

Filling your tank with gas

The fuel line for the human body to fill its energy storagetanks, especially the largest energy storage tank fat, isinsulin. Insulin is the hose that energy (gasoline, biodiesel)flows from the storage tank (breakdown products of your recently ingested meals) into your gas tank for future use.Without this fuel line insulin, you will eventually go intoa coma (hyperosmolar) that if not treated, can result in lessthan optimal outcomes.

Using the gas in your tank

When we drive our cars, we use the energy stored in the fueltanks. In order for us to use that fuel, it must get fromthe storage tank to the motor. In the human, that fuel lineis glucagon. Remember, insulin stores energy, glucagonutilizes that stored energy. Just as insulin stimulates energy storage and the necessary enzyme systems, glucagonstimulates energy utilization and the necessary enzyme systems required to accomplish this.

Life in the Fed State

The problem today is that we have evolved from creatures thatdid not have consistent daily feedings to our "modern" fastfood insanity and the notion that now we need three "square"meals a day plus snacks. What happens to our energy metabolismwhen we start out putting insulin stimulating foods in ourstomach three times a day? When we eat, our biochemistryreacts by secreting insulin, so that we can store all thisenergy for future needs -most of it going into fat. Longbefore we have used any of this energy, we are having anothermeal -lunch. More gas in our tanks, -none used yet. Then comes dinner -more gas into our tank. Snacks -more gas in.We spend our whole day and most of the night in a "fed" orinsulin state.

Huge fuel tanks full of fat -everywhere

Because we never allow our body's insulin level to drop enoughso that the glucagon level will rise, we never get into a "glucagon" state. Our whole car is now filled mostly withgas. There is hardly any room for a driver in the front seat.Huge fuel tanks full of fat are everywhere we look. Yourcar is loaded with gas, but you can't drive around the blockbecause you haven't developed the enzymes of energy utilizationto establish a fuel line between all these gas tanks fullof fat and our motor, which is now also encased in fat.While insulin is the fuel line to fill our energy stores, glucagon is the fuel line to use this stored energy. Withoutproper stimulation of the glucagon system, our tanks justkeep filling up with fat. We never develop the necessaryenzymes to use all this energy. You don't have to travel toofar to see people totally encased in their stored energy.

Livin' la vida de glucagon

To break this cycle, we need to stop eating for at least a portion of the day, or at least every other day. I don't knowhow many of you have ever fasted for 24 hours or more, but the feeling is incredible. You get a lot more work done,you don't get lethargic after eating and you start to actuallyfeel thin. I don't recommend fasting more than 24 hoursand I am not actually recommending a 24 hour fast. What Iam recommending is that during some portion of every day orat least every other day, you refrain from eating anythingso that you can get into a glucagon state and begin to inducethe necessary enzymes to use all the energy the human bodycan store.

Summary

Like it or not, three meals a day plus snacks is just not healthy.

Copyright John Mericle M.D. 2005 All Rights Reserved

To sign up for Dr. Mericle's Newsletter or visit the MericleDiet please click on the link below.

http://www.DrMericle.com

DrMericle.com is devoted to achieving optimal health and peak performance through diet and lifestyle change. Dr. Mericle brings together a unique blend of formal training in organic chemistry and biochemistry, medical education, 29 marathons, 3 Hawaii Ironman competitions and a lot of practical real life experience.


MORE RESOURCES:

9 ways to keep your weight loss resolution
9NEWS.com
Holly Wyatt, MD is associate director and medical director of the University of Colorado Anschutz Health and Wellness Center and co-author of "State of Slim", was on the 9NEWS weekend morning show with the steps you need to make weight loss happen. 1.



Weight loss: It's in your mind
Richmond Register
That's why weight loss requires patience. There's little point in checking the bathroom scale on a daily basis to see how much weight you've lost. Remember, it probably took you years to put on the extra weight. Don't expect to take it all off in two ...



CBS News

New Weight Loss Drug Saxenda: FAQ
WebMD
24, 2014 -- A drug that treats type 2 diabetes has gotten FDA approval for another use: weight loss. Saxenda is the fourth drug for weight loss OK'd by the agency since 2012. It's already available in a lower dose as Victoza for type 2 diabetes ...
New weight-loss drug wins FDA approvalCBS News
New Weight Loss Drug Approved By FDA: Compare Diet Pills, Diets, And ...The Inquisitr
FDA approves Novo Nordisk's weight loss injection, SaxendaNews-Medical.net
Columbus Ledger-Enquirer -FDA.gov
all 126 news articles »


Cafecito: Comedian Iglesias Discusses Rise to Fame, Weight Loss
NBC Southern California
Comedian Gabriel "Fluffy" Iglesias discusses his rise to fame and what inspired him to lose 100 pounds on this week's Cafecito. (Published Saturday, Dec 27, 2014). Saturday, Dec 27, 2014 • Updated at 10:37 PM PST. Comedian Gabriel “Fluffy” Iglesias ...



UCLA's Ellis McCarthy is more effective on defense after weight loss
Los Angeles Times
UCLA defensive lineman Ellis McCarthy said he has lost 10 pounds. It looks like more. He certainly has been playing as if it is more. McCarthy was listed at 330 pounds when the season began. His redesigned shape, a combination of diet and ...



MLive.com

Kalamazoo couple turns weight loss surgery into a joint project and loses 350 ...
MLive.com
Through the years, they both tried weight loss plans, even dieting together before they got married. But, diets never really seemed to work. "I've tried Weight Watchers and Atkins and just low-cal and low-fat. I did Weight Watchers maybe six times. I'd ...



Science World Report

FDA Approves Weight-Loss Drug, Saxenda
News Every day
The U.S. Food and Drug Administration (FDA) has approved a new injectable weight-loss drug, Saxenda (liraglutide), for obese adults or overweight adults with at least one weight-related health problem. Weight-related health conditions include ...
FDA Approves New Weight-Loss DrugScience World Report
New Weight Loss Drug Saxenda Approved By FDAHeadlines & Global News
Weight-loss drug, Saxenda, wins FDA approvalPress TV
Bidness ETC
all 21 news articles »


KABC-TV

Weight-loss supplements pose major health risks, study says
KABC-TV
But a new Consumer Reports survey of about 3,000 Americans shows one in four has used weight loss supplements. The survey also found more than 90 percent couldn't lose the weight they wanted and keep it off. About half reported at least one side effect ...



Fox News

The 10 biggest food and weight loss stories of 2014
Fox News
I can't believe it's been a year since I compiled my last round-up, but it's that time again! As a research junkie, I think this year's crop of studies in the areas of nutrition and weight management have been particularly fascinating. Here are my top ...
10 Biggest Food and Weight Loss Stories of 2014TIME

all 2 news articles »


Dallas Morning News (blog)

Dallas Cowboys DE Jeremy Mincey credits weight loss of 25 to 30 pounds this ...
Dallas Morning News (blog)
Dallas Cowboys defensive end Jeremy Mincey (92) rushes Houston Texans quarterback Ryan Fitzpatrick (14) during the Houston Texans vs. the Dallas Cowboys NFL football game at AT&T Stadium in Arlington on Sunday, October 5, 2014.

and more »

Google News


Advertisement



Section Site Map - Submit News - Feedback - Comments - Advertise with Us

Copyright 2006 Luminati Inc. All rights reserved.