Bookmark Website  | Free Registration  | The Team
The Lounge  | Champions  | The Wire |  Schedule |  Audio  |  Arcade  |  The Top Ten  |  Historical  |  Email  |  Video

Safe and Permanent Weight Loss Cannot Be Achieved in the Fed State


Weight Loss Axiom Number Three

Insulin and Glucagon

These are the two major hormones that control energy metabolism in the human. They are much like yin andyang, hot and cold or happy and sad. In order to really enjoy the good days, we all have bad days. Extremes of eithertoo hot or too cold and soon everyone complains about the weather. Too much yin or too much yang and according to traditional Chinese Medicine, you are sick. Too much insulinand you are sick, hypertension, overweight, cancer, heart disease and stroke. Too much glucagon and you are toothin, emaciated and weak.

As we have mentioned previously, when man evolved there wouldbe times of famine, between times of feast. The biochemistry of this evolution allowed man to survive the periods of famineby using insulin to "store" energy. Some typical "fuel" reserves in a 70 kilogram man:

Organ ***************** Available energy (kcal)
************ glucose/glycogen ***** fat ***** protein
blood *********** 60 ************** 45 ********* 0
liver *********** 400 ************* 450 ******** 400
brain *********** 8 *************** 0 ********** 0
muscle ********** 1200 ************ 450 ******** 24000
adipose(fat) **** 80 ************** 135,000 **** 40

from Stryer Biochemistry 4th Edition page 771

Look at the chart and find the biggest number. The largestamount of available energy in an average 70 kilogramhuman is overwhelmingly stored in -fat. For the purpose ofthis discussion let's think of each of these numbers aboveas fuel tanks, for our energy needs. When we fill up ourcars with gasoline (our old Mercedes B100 biodiesel) we haveto have a fuel hose to get the fuel into our gas tank. Inorder to use that fuel in our gas tanks, we have to have afuel line leading from the gas tank to the motor in ourcar. Without these fuel lines, we could not utilize ourengine / car.

Enzymatic Induction

Human biochemistry is composed of many different enzyme systems.One such enzyme is phosphofructokinase that catalyzes the reaction of fructose 6-phosphate to fructose 1,6-bisphosphate.As with any biochemical reaction that is dependant on anenzyme system, the more it is used, the more developed itbecomes. If there is no need for an enzyme, then the levelsin the body will be very low. If there is much demand for an enzyme, then the body will synthesize more of it to meetthe demands.

Filling your tank with gas

The fuel line for the human body to fill its energy storagetanks, especially the largest energy storage tank fat, isinsulin. Insulin is the hose that energy (gasoline, biodiesel)flows from the storage tank (breakdown products of your recently ingested meals) into your gas tank for future use.Without this fuel line insulin, you will eventually go intoa coma (hyperosmolar) that if not treated, can result in lessthan optimal outcomes.

Using the gas in your tank

When we drive our cars, we use the energy stored in the fueltanks. In order for us to use that fuel, it must get fromthe storage tank to the motor. In the human, that fuel lineis glucagon. Remember, insulin stores energy, glucagonutilizes that stored energy. Just as insulin stimulates energy storage and the necessary enzyme systems, glucagonstimulates energy utilization and the necessary enzyme systems required to accomplish this.

Life in the Fed State

The problem today is that we have evolved from creatures thatdid not have consistent daily feedings to our "modern" fastfood insanity and the notion that now we need three "square"meals a day plus snacks. What happens to our energy metabolismwhen we start out putting insulin stimulating foods in ourstomach three times a day? When we eat, our biochemistryreacts by secreting insulin, so that we can store all thisenergy for future needs -most of it going into fat. Longbefore we have used any of this energy, we are having anothermeal -lunch. More gas in our tanks, -none used yet. Then comes dinner -more gas into our tank. Snacks -more gas in.We spend our whole day and most of the night in a "fed" orinsulin state.

Huge fuel tanks full of fat -everywhere

Because we never allow our body's insulin level to drop enoughso that the glucagon level will rise, we never get into a "glucagon" state. Our whole car is now filled mostly withgas. There is hardly any room for a driver in the front seat.Huge fuel tanks full of fat are everywhere we look. Yourcar is loaded with gas, but you can't drive around the blockbecause you haven't developed the enzymes of energy utilizationto establish a fuel line between all these gas tanks fullof fat and our motor, which is now also encased in fat.While insulin is the fuel line to fill our energy stores, glucagon is the fuel line to use this stored energy. Withoutproper stimulation of the glucagon system, our tanks justkeep filling up with fat. We never develop the necessaryenzymes to use all this energy. You don't have to travel toofar to see people totally encased in their stored energy.

Livin' la vida de glucagon

To break this cycle, we need to stop eating for at least a portion of the day, or at least every other day. I don't knowhow many of you have ever fasted for 24 hours or more, but the feeling is incredible. You get a lot more work done,you don't get lethargic after eating and you start to actuallyfeel thin. I don't recommend fasting more than 24 hoursand I am not actually recommending a 24 hour fast. What Iam recommending is that during some portion of every day orat least every other day, you refrain from eating anythingso that you can get into a glucagon state and begin to inducethe necessary enzymes to use all the energy the human bodycan store.

Summary

Like it or not, three meals a day plus snacks is just not healthy.

Copyright John Mericle M.D. 2005 All Rights Reserved

To sign up for Dr. Mericle's Newsletter or visit the MericleDiet please click on the link below.

http://www.DrMericle.com

DrMericle.com is devoted to achieving optimal health and peak performance through diet and lifestyle change. Dr. Mericle brings together a unique blend of formal training in organic chemistry and biochemistry, medical education, 29 marathons, 3 Hawaii Ironman competitions and a lot of practical real life experience.


MORE RESOURCES:

The 5 Weight Loss Tips That Work for My Clients—Every Time
Parade
Nutrition-wise, there are five principles that I stress to my clients. They are basic, no-nonsense weight loss tips. And when my clients follow them, they become the envy of their friends! If you are able to focus on these five things, I promise that ...



Examiner.com

Woman Credits Hypnosis for 140-Pound Weight Loss
ABC News (blog)
Is the secret to weight loss simply tricking your mind into thinking you had gastric bypass surgery? That's what happened to Julie Evans, an overwhelmed mom of two small children, who at her biggest weighed 287 pounds. Evans claims hypnosis helped her ...
Gastric bypass hypnosis aided woman's shocking 140-pound weight lossExaminer.com

all 7 news articles »


Men, substance users less likely to have weight-loss surgery
Yahoo News
NEW YORK, (Reuters) - A one-size-fits-all approach to weight-loss surgery may be keeping obese men, substance users and older people out of the operating room, a new study suggests. The study analyzed data from a Canadian program intended to ...

and more »


Extreme Weight Loss Kenny and Christy [Recap/Review]
Guardian Liberty Voice
On Extreme Weight Loss on ABC tonight, Chris and Heidi Powell the transformational coaches and trainers who host the show, will have their hands full when they take on two competitors, Kenny and Christy. Kenny, who is a former Marine, weighs in at the ...
For the first time ever someone gets kicked off “Extreme Weight LossWOTV
ABCS's 'Extreme Weight Loss' Preview: Meet ChristyAccess Hollywood
Christy Oldenkamp, Extreme Weight Loss: Photos, Video of Las Vegas Woman ...The Epoch Times
Empty Lighthouse Magazine
all 8 news articles »


Insurance Journal

Wearable Device for Weight Loss Or Unbearable Loss of Privacy?
Insurance Journal
To fight rising medical costs, oil company BP Plc last year offered Cory Slagle — a 260-pound former football lineman — an unusual way to trim $1,200 from his annual insurance bill. One option was to wear a fitness-tracking bracelet from FitBit Inc ...

and more »


The mind-body shift — from weight loss to weight room
SFGate
It happened in 2007, and not altogether on purpose. I lost 30 pounds in five months in the midst of a divorce. I had been married for almost 15 years, and the last few had been bad. We'd seen three couples counselors and I had tried my best to make ...



9 Possible Causes of Feline Weight Loss
Catster
If your cat is losing weight and you're not dieting her with the guidance of your veterinarian, there are a lot of reasons this could be happening. Any of them could mean your cat's health is in jeopardy, so please don't ignore your cat's weight loss ...

and more »


Weight loss formula: take the entertainment out of food
STLtoday.com
Karen “KJ” Luther's story of going from 387 pounds to 142 pounds wasn't supposed to be a triumph for anyone but her. Then, she posted her stories on Facebook. “It sounds like a fairy tale. But after my before and after photo appeared on Facebook, so ...



In Touch Weekly

Snooki to Weight Loss Lawsuit — “Who Says Diet Pills Mean Weight Loss?!"
In Touch Weekly
In 2013, Snooki was hit with a lawsuit by a woman who was disappointed with her results on the diet pill Zantex—which the Jersey Shore star attributed for her impressive slim down. And now the pint-size celeb is firing back—by saying she never ...
Snooki Responds To Weight Loss LawsuitDaily Times Nigeria

all 6 news articles »


KyForward.com

Weighty Matters: Stuck in a weight-loss crawl, motivation is needed to get me ...
KyForward.com
We've all heard the saying that “you have to crawl before you can walk.” Well, I have to face the fact that seven months after I began my weight loss journey with the birth of my granddaughter, I'm still crawling and she's climbing stairs! I don't ...


Google News


Advertisement



Section Site Map - Submit News - Feedback - Comments - Advertise with Us

Copyright 2006 Luminati Inc. All rights reserved.