Bookmark Website  | Free Registration  | The Team
The Lounge  | Champions  | The Wire |  Schedule |  Audio  |  Arcade  |  The Top Ten  |  Historical  |  Email  |  Video

Reviving Vitamin E Studies That Challenge Claims of Wonder Supplement Also Leave Openings


The last year hasn't been a good one for vitamin E.

Once considered a wonder supplement, an inexpensive and harmless pill that might prevent heart disease, cancer and Alzheimer's, a flurry of recent clinical trials suggest it does none of those things.

Some even suggest there is a small chance it could be harmful in higher doses.

Yet while the oily little capsule apparently can't keep people alive longer, it refuses to die, in part because in nearly every one of the recent negative studies some caveat or contradictory finding creates a glimmer of hope.

It also doesn't hurt that the dietary supplement industry continues to promote vitamin E and offers experts to refute some of new research.

"It doesn't go away," said Edgar Miller, a vitamin E researcher and associate professor of medicine at Johns Hopkins University. "Why does it keep selling when there are so many of these negative studies?"

The answer appears to be a combination of factors, including years of promising laboratory, animal and epidemiological studies; heavy promotion by the dietary supplement industry; and, more recently, contradictory findings within studies showing no overall benefit.

The required daily amount is 22 IU (international units). Many recent clinical trials have ranged from 300 IU to 2,000 IU.

Recent clinical trials of high-dose vitamin E have led some researchers to speculate that vitamin E in megadoses may increase the oxidation of LDL cholesterol, the bad kind.

When cholesterol is oxidated, it contributes to coronary artery disease.

There also is some concern that high amounts of vitamin E may displace other beneficial anti-oxidants from that average person's diet.

Combining studies

Consider these recent studies: In November, a vitamin E bombshell was dropped by Johns Hopkins University researchers at an American Heart Association meeting.

They pooled 19 clinical trials of vitamin E involving 136,000 patients.

In 11 of the high-dose trials (400 IU or more), the risk of dying from any cause increased 4%, compared with people taking placebos.

Prior to that finding, vitamin E had been considered, at worst, harmless.

"People take anti-oxidants because they want to live longer," said Miller, an associate professor of medicine. "What we showed is you don't live longer."

However, the analysis also suggested that lower doses of vitamin E (less than 150 I.U. a day) were associated with about a 2% reduction in deaths.

Researchers acknowledged several potential shortcomings in their study.

For instance, they noted that several of the high-dose trials involved people with various chronic diseases and may not apply to healthy individuals.

They also said the small size of several of the trials in the analysis and inconsistent reporting of health events prevented a detailed look at the effect of various doses of the vitamin.

"It's a very flawed analysis," said Julie Buring, a professor of medicine at Harvard Medical School who recently presented her own vitamin E research.

She also said the 4% increased risk of death was not "clinically meaningful" and could be a chance finding.

Women's health study

On March 7, Buring and other Harvard scientists presented their own vitamin E study at the American College of Cardiology annual meeting.

Once again, the vitamin threw researchers a curve.

Analyzing data from the Women's Health Study, a trial involving 40,000 women who got either 600 IU of vitamin E every other day or a placebo, researchers found that it provided no overall cardiovascular benefit such as reduction in heart attacks or strokes.

However, an analysis of a subgroup of women over 65 found a 26% reduction in cardiovascular events.

Buring said that although the finding was "intriguing," it was not supported by previous research.

She added that it needs confirmation.

Adding even more confusion, the study found a statistically significant 24% reduction in cardiovascular deaths among all the vitamin E users.

Buring also questioned that finding because there was no overall reduction in strokes and heart attacks. She said it was possible that it was due to other cardiovascular causes such as arrhythmias or heart failure, but there was no reasonable biological explanation for that.

"People should look at that further, but it could be chance," she said.

Buring concluded that vitamin E was neither harmful nor beneficial in preventing cardiovascular disease.

A surprise

About a week after the Women's Health Study, another controversial vitamin E finding was presented.

The study involved 9,500 people aged 55 and older with vascular disease or diabetes who were followed for an average of seven years.

It found that 400 IU of vitamin E a day provided no protection against cancer or major vascular events such as heart attacks or strokes.

In addition, the study found a disturbing 13% increase in heart failure cases and 21% increase in heart failure hospitalizations.

That was the first time that vitamin E had been associated with an increased risk of heart failure, said lead author Eva Lonn, a professor of medicine at McMaster University in Hamilton, Ontario.

"I am not convinced about the harm," Lonn added.

Indeed, a recent small study of heart failure patients taking a cholesterol-lowering statin drug suggested that vitamin E actually increased the statin's ability to improve blood vessel function and lower inflammation.

Lonn and the other researchers said a review of all heart failure events in large vitamin E clinical trials "is strongly recommended."

Confounding the heart failure finding was what appeared to be a statistically significant 28% reduction in lung cancer cases, although in a secondary analysis of the data the benefit seemed to disappear.

"The numbers are small," Lonn said. "We think it's a chance finding."

The researchers noted that other larger vitamin E trials showed no lung cancer benefit.

Alzheimer's research

There still is some hope that vitamin E might help prevent Alzheimer's disease, although in May a clinical trial of 769 patients with mild cognitive impairment found it was of no benefit in delaying the progression to Alzheimer's.

In that trial, the patients took a mega dose 2,000 IU a day for up to three years, according to the findings in the New England Journal of Medicine.

Other vitamin E / Alzheimer's trials are ongoing.

The anti-oxidant vitamin enthusiasm of the 1990s is being tempered by clinical trials, according to a JAMA editorial that accompanied the Women's Health Study results.

"These hopes are now confined to modest expectations for specific disorders and there are concerns about adverse effects," the editorial said.

Mike Freije from Health Shop
http://www.health-shop.com
http://www.health-shop.info


MORE RESOURCES:

CBS News

FDA warns consumers: Dietary supplements cannot treat concussions
CBS News
The U.S. Food and Drug Administration is warning consumers about dietary supplements that falsely claim to prevent or cure concussions or other traumatic brain injuries. The FDA says supplements with labels that make these claims are not backed up by ...
Steer Clear of Dietary Supplements for Concussions: FDAPhilly.com

all 21 news articles »


Medical News Today

Vitamin D supplements 'do not reduce risk of heart attack or stroke'
Medical News Today
Past research has suggested that individuals with low levels of vitamin D are at higher risk of cardiovascular disease. Now, a new study led by researchers from the University of East Anglia in the UK claims that taking vitamin D supplements will not ...



Beware Of Dietary Supplements Claiming To Treat Concussion, FDA Says
Huffington Post
Dietary supplements are not subject to the same regulations that medications are, which means that supplements can enter the market without undergoing the rigorous testing that medicines do. After a supplement is on the market, the FDA can send warning ...

and more »


New Scientist

A to zinc: What supplements are worth taking?
New Scientist
Vitamins, minerals, fish oils… the list of nutritional supplements you can buy keeps growing. Some are worth it, some aren't. We sift the evidence for you. IN 1911, Polish chemist Casimir Funk made one of the most influential biomedical discoveries of ...



Fox News

Beware Of Fake Ebola Supplements
Forbes
The FDA is warning consumers today to be aware of supplements and other products sold online that are fraudulently marketed to treat or prevent Ebola virus infection. We currently have no agents – drug, dietary supplement, herbal supplement – that can ...
Beware of Ebola Supplements Sold Online, Warns FDAMonthly Prescribing Reference
Fake Ebola Treatments Are Popping Up On The Internet: The FDA Warns ...Medical Daily
Beware Fake Ebola Treatments on the Internet, FDA SaysWebMD
Bangor Daily News
all 407 news articles »


Fox News

The supplements that could slash your risk of sun damage
Fox News
After 85 days of treatment, the combined supplements increased the amount of UV exposure needed to cause sunburn by 56 percent. In the second, a group of 20 volunteers took a blood orange supplement and saw protective effects after only 15 days. By the ...



New Vitality Health Foods, Inc. Provides Tips On How Nutritional Supplements ...
DigitalJournal.com
In the 26 years New Vitality Health Foods, Inc. has been serving its customers, it has grown to become a nutrition resource center for its patrons. New Vitality Health Foods, Inc. offers a wide variety of homepathic's, vitamins and nutritional ...

and more »


5 Supplements That May Help With Depression
The Epoch Times
Over two-thirds of Australians are thought to use complementary medicines ranging from vitamin and mineral supplements to herbal to aromatherapy and homeopathic products. Mental health concerns are one of the reasons why people use supplements, but ...

and more »


NJSIAA offering help in determining if ingredients in supplements are approved
The Jersey Journal - NJ.com
It can be confusing to parents, coaches and student-athletes throughout the state just what athletic supplements contain steroids or other ingredients that haven't been approved by the New Jersey State Interscholastic Athletic Association (NJSIAA).



PLoS Blogs (blog)

Do multivitamin supplements increase mortality risk?
PLoS Blogs (blog)
The top headline on the 'Most Read' side panel instantly caught my eye: 'Dietary Supplements and Mortality Rate in Older Women'. Reading, I was amazed to find that taking multivitamins, vitamin B6, folic acid, magnesium, zinc, copper, and in particular ...


Google News


Advertisement



Section Site Map - Submit News - Feedback - Comments - Advertise with Us

Copyright © 2006 Luminati Inc. All rights reserved.