|The Lounge | Champions | The Wire | Schedule | Audio | Arcade | The Top Ten | Historical | Email | Video|
Congestive Heart Failure And CoQ10
Since the 1960â??s there have been numerous controlled clinical trials concerning the relationship between congestive heart failure and Coenzyme Q10 (CoQ10). As its name implies CoQ10 is a coenzyme that is necessary for the proper functioning of other substances, one of the most important of which is ATP (adenosine triphosphate). ATP is necessary for the production of cellular energy. By proxy CoQ10 is likewise essential for this process.
Clinical trials have attempted to study the relationship between CoQ10 and many chronic diseases including, but not limited to, heart disease, cancer and AIDS. But heart disease has gained the most attention; congestive heart failure being one of the primary subjects. Because heart muscle cells require so much energy to function and CoQ10 is at the core of the cellular energy process it makes sense to suspect that congestive heart failure might be linked to CoQ10 deficiency. With that theory in mind many studies like the ones that follow have been conducted. These trials have been presented in this essay in thumbnail format.
One early Japanese trial (1972) involved 197 patients with varying levels of severity of cardiac failure. The study reported significant improvement of cardiac function supplementing with 30 mg per day of CoQ10. Another Japanese study demonstrated similar results with 38 patients also supplementing with 30 mg. In 1985 a U.S. clinical study prescribed daily supplementation with 100 mg of the coenzyme for treatment periods of three months for patients with low ejection fraction measurements. The ejection fraction is the measure of the heartâ??s ability to pump blood. A low ejection fraction is a classic symptom of congestive heart failure. Again, significant improvements in heart function were reported. Other clinical trials followed prescribing the same level of supplementation with similar results.
Studies in the early 1990s showed improvement for patients suffering from ischemic cardiomyopathy (a low oxygen state usually due to obstruction) with supplemental levels of 200 mg per day. Supplementing with 100 mg per day demonstrated improvement for patients suffering from idiopathic dilated cardiomyopathy, an enlarged heart syndrome of unknown cause.
One of the largest trials of the 1990s involves 641 patients randomly divided into two groups. The first group received a placebo. The other group received CoQ10 supplements. During the one-year follow-up period 118 patients in the placebo group were hospitalized for heart failure compared to 73 in the group that received the supplements.
All of the preceding trials were relatively short-term studies. The level of improvement among patients varied depending on how long they had been suffering from some aspect of congestive heart failure. Through the years it has become increasing clear that the greatest improvements were shown in patients that had suffered from their condition the least amount of time.
In other words, the longer a person had been suffering from the disease before he or she received CoQ10 treatments the less improvement was demonstrated. People who had received treatments early in the development of the disease showed the most dramatic improvement often returning to normal heart function. Long-term sufferers received less relief and were less likely to return to full heart function. Whatever the reasons for this disparity in health improvement, it demonstrates the importance of receiving treatment as early as possible.
But what about long-term studies? Do they show the same marked improvement with similar treatment? In the short-term trials it was apparent that even high level supplementing with CoQ10 seemed to produce no ill effects. In order to determine if this is only true for short durations a number of long-term studies were conducted.
In 1990 observations were published concerning 126 patients with dilated cardiomyopathy. Unlike previously noted studies this one followed the patientsâ?? progress for six years. Long-term benefits from CoQ10 supplementing were noticed with no harmful side effects. Similar observations were made in a trial involving 2,664 patients treated with CoQ10 at levels up to 150 mg per day.
A 1994 study involving 424 patients with a variety of myocardial (refers to the heart's muscle mass) diseases. Among these conditions were the following: Valvular heart disease (pertaining to dysfunction of heart valves), hypertension, diastolic dysfunction (failure of the heart to properly refill itself with blood), dilated cardiomyopathy (group of disorders where the heart muscle is weakened and enlarged and cannot pump effectively) and ischemic cardiomyopathy (low oxygen state usually due to obstruction of the arterial blood supply).
Patients were treated with an average of 240 mg of CoQ10 daily during their treatment period. They were then followed-up for up to eight years with an average follow-up period of 18 months. Overall results demonstrated measurable cardiac improvements in one month with maximum improvements at about six months. With continued CoQ10 treatment the improvement in most patients was sustained. However, discontinuing the treatment usually resulted in a decline of cardiac function with eventual return to pre-treatment conditions.
As always in the medical community many more studies will need to be conducted to determine the future of CoQ10 treatment. However, the research to date seems to support CoQ10 as a viable treatment for many diseases that are caused or exacerbated by inadequate production of cellular energy.
Greg holds degrees in science, divinity and philosophy and is currently an I.T. developer.
Industry body welcomes EU 'correction' on silicon dioxide and silicate in ... - NutraIngredients.com
HGH - Avoid Getting Ripped Off
HGH is an exciting new phenomenon, which aspires to help us defy age, build muscle, increase vitality, and improve our quality of life in ways we have not yet discovered. Understandably, the public desperately needs and wants these benefits and is spending large amounts of money on growth hormone products.
Sports Supplement - what is it?We are all aware of what is a nutrition or diet supplement, but what is a sports supplement? A sport supplement is a subcategory of nutrition supplements. The sports supplement is associated with rising sport results, intensifying training, lowering the consequences like muscle pane, etc.
Fatty Acids Could Protect Against Parkinson's
Both types of unsaturated fatty acids are contained within neuronal cell membranes and are known to have neuroprotective, antioxidant, and anti-inflammatory properties.The researchers involved in the new study, published in Neurology (2005;64:2040-2045), wanted to build on this knowledge by determining whether a high intake of unsaturated fatty acids might be associated with a lower risk of Parkinson's disease.
Take Back Your Life 3
In parts one and two of this series, titled "Take Back Your Life" and "Take Back Your Life 2"; we discussed the importance of proper cell function and the necessity of having and maintaining a balanced endocrine system as they relate to wellness. Here in part 3, we shall examine why vitamins and minerals, including certain trace minerals are absolutely necessary to further insure and maintain a state of wellness and optimum health.
Body Building Supplementation
Body Building Supplement - what is it?The term "body building supplement" is familiar to almost everyone nowadays. Body building supplement is a supplement that is designed to help people who use it to achieve several things that include but are not limited to weight gain, muscle building, and strength training.
Can Calcium Aid in Boosting Your Health?
A popular mineral today, coral calcium, is mainly calcium, but is also abundant in many trace sea minerals. Some people consider coral calcium to be nature's purest calcium supplement.
Glyconutrients - The Next Major Health Breakthrough
Did you know?· 20% of Australian children reported symptoms of Asthma in the past year.· 60% of Australians are overweight with 20% obese.
The Perfect Supplement
I wanted to write this article because of my sincere belief thateverybody in the world should be taking the product I am about totalk about "Greens First". This product contains over 49 superfoods and tastes absolutely delicious.
Riboflavin for Migraine Headache Relief
Supplementing with relatively small amounts of riboflavin (vitamin B2) may reduce the severity and frequency of migraines in chronic sufferers, reports a study in Headache (2004;44:885-90). Previous studies showing that riboflavin can prevent migraines used 400 mg per day, which is at least 200 times the amount in a typical diet.
Should I Be Taking Vitamin Supplements?
Most people believe that they are reasonably healthy. Exercise, having a solid diet, and keeping stress to a minimum is a great way to live a longer, happier, and healthier life.
Safer And More Effective Than Botox? Shocking Results
Are the new Argireline Wrinkle Relaxing Creams as effective as Botox?For many women, wrinkles and fine lines are the bane of their lives. Looking into the mirror and seeing a face filled with wrinkles, sagging skin, and fine lines can be very disheartening, but it's all a part of growing old, right?Well, yes and no.
Health Benefits of CoQ10 - A Powerful, Important Heart Compound
Coenzyme Q10 (also known as ubiquinone, but most widely referred to as CoQ10) is a substance that can be found in every cell of the body, where it is used to produce the large amounts of energy needed for healthy cell growth, repair after damage, and maintenance.CoQ10 also functions as a powerful antioxidant, which protects the cells and the entire body from damage caused by harmful molecules.
Know Your Bodybuilding Supplement - L-Carnitine
L-carnitine is synthesized in the body from the amino acids lysine and methionine but it can also be found in nutritional sources such as red meats, dairy products and avocados. Its main role in the body is to help metabolize food into energy.
Vitamin Euphoria - A Shot in the Dark
Vitamins seem to be so good for everything. The newly born needs them to grow properly; women take them to be happy; men use them to maintain or increase potency; athletes ingest them to stay fit; and older people take them to become younger or to avoid the flu.
Appreciating the Importance of Folic Acid
Folic acid is actually just one of the many vitamins that make up the Vitamin B complex. Also known as folacin and folate, this indispensable nutrient serves the body in more ways than one.
Balancing Your Hormones Naturally -- What To Do First
One of the questions that I frequently get asked is "What steps do I need to take to begin getting my hormones in balance?" The following is what I suggest:Test your hormone levels. This should be done by utilizing both saliva testing and blood testing.
Amino Acid Basics - Why Do We Need Them?
Finding out a little about amino acid basics enables you to get an insight into why these acids are so important to our bodies. These acids are known as the building blocks of protein, and they are vital to our bodies for many reasons.
Advanced Creatine Cycling Schedule
Many people find that after a few weeks, the gains they make on creatine monohydrate begin to taper off or even disappear altogether. There's an increasing belief among hardcore trainers that cycling creatine intake may help one experience continued progress with this proven supplement.
Antioxidants Nutrients Have Powerful Anti-Cancer Activity!
Antioxidants . .
Too Many Books, Supplements, and Programs
If I read 1 good valid murder mystery book, would I really want that to be the ONLY book on the subject? If my 8th grade history book was considered to be accurate by the majority would I really want to be limited to only knowing one author's thoughts on the subject? Or how about browsers and music players? Do I just want to use IE? It gets the job done well enough.So what's the difference between those analogies and fitness ebook, supplements and programs? Really there's no difference to me.
Section Site Map - Submit News - Feedback - Comments - Advertise with Us
Copyright © 2006 Luminati Inc. All rights reserved.