Bookmark Website  | Free Registration  | The Team
The Lounge  | Champions  | The Wire |  Schedule |  Audio  |  Arcade  |  The Top Ten  |  Historical  |  Email  |  Video

The History And Usefulness Of Coenzyme Q10


Throughout my childhood I was aware of the importance of eating well and taking my vitamins. But the science of dietary supplements has come a long way since those days. And one of the stars in this scientific progression is Coenzyme Q10 (CoQ10). CoQ10 is not a drug. It is a vitamin-like substance that is found in small amounts in a variety of foods and is synthesized within our body tissues.

Enzymes are compounds in the body that are absolutely essential for the many processes necessary to keep us alive and our bodies functioning properly. Mitochondrial enzymes are those particular enzymes that are essential for the production of the high-energy phosphate ATP (adenosine triphosphate) upon which all cellular function depends. Without it our bodies shut down at the cellular level. Coenzyme Q10 is the cofactor upon which at least three mitochondrial enzymes depend. By logical inference then ATP functioning depends upon CoQ10. In short, all human cellular function depends on ATP. And ATP function depends on CoQ10.

As was already said, the production of CoQ10 occurs within our body tissues. Its biosynthesis from the amino acid tyrosine is a complex multistage process requiring several vitamins and trace elements. Under normal conditions we produce all we need while we are young. But there are many factors that can contribute to CoQ10 deficiency. Among these are aging, disease, dietary deficiency, use of statin drugs and increasing tissue demands. Before we get to CoQ10 deficiencies, however, it is well to look at the history of CoQ10 research.

History

CoQ10 was first isolated by Dr. Frederick Crane in 1957 from the mitochondria of beef heart. During that same year Professor Morton, from Britain, also discovered CoQ10 in the livers of vitamin A deficient rats. During the following year researchers at Merck, Inc. determined its chemical structure and became the first to produce it.

It was neither the British nor the Americans that first found a practical use for the CoQ compounds. Professor Yamamura from Japan first used a related compound (CoQ7) in the treatment of congestive heart failure. Other practical uses then followed. CoQ6 was used as an effective antioxidant in the mid 1960s. In 1972 (in Italy) deficiency of CoQ10 was linked to heart disease. The Japanese, however, were the first to perfect the technology necessary to produce CoQ10 in sizeable enough quantities to make large clinical trials a reality.

After Peter Mitchell won the Nobel Prize in 1978 for defining the biological energy transfer that occurs at the cellular level (for which CoQ10 is essential) there was a considerable increase in the number of clinical studies performed in relation to CoQ10 usefulness. This was due in part to the large amounts of pharmaceutical grade CoQ10 that was now available from Japan and the ability to measure CoQ10 in blood and body tissues. CoQ10 since has become known for its importance as a powerful antioxidant and free radical scavenger and as a treatment in many chronic illnesses, especially heart disease.

Coenzyme Q10 Deficiency

The usefulness of CoQ10 as a medical treatment has largely been approached from the perspective that when a chronic disease is present (especially in the case of heart disease) CoQ10 is often grossly deficient. For example, a person suffering from congestive heart failure often demonstrates extreme CoQ10 deficiency. Normal blood and tissue levels of CoQ10 have been well established. Significantly low levels of CoQ10 have been linked to a vast variety of diseases in both animal and human studies.

But if CoQ10 is biosynthesized in our bodies why do we often suffer from deficiency? There are at least three causes. The first is an insufficient diet. Dietary intake of CoQ10 is an important factor in total blood and tissue levels of the compound. If we do not consume enough of the foods that contain CoQ10 then the body must make up the difference. Further, the biosynthesis of Coenzyme Q10 is a complex 17-step process involving a whole string of B vitamins, vitamin C and pantothenic acid. Diets deficient in these compounds make CoQ10 synthesis impossible. This is not the place to discuss the condition of the average diet and the vitamin deficient nature of many of our food sources. Suffice it to say that most of us do not get nearly enough CoQ10 or the other vitamins necessary for optimal synthesis.

The second cause of deficiency is linked to the first, and that is impairment of CoQ10 biosynthesis. In addition to inadequate intakes of the compounds necessary to make CoQ10 there are other biological reasons for inadequate production of it. These might include physiological conditions and chronic diseases that cause failure in production. The treatments of diseases can also be a factor. For instance the use of statins to control cholesterol levels has been implicated in the depletion of CoQ10 levels. The catch-22 is, in treating heart disease we use drugs that deplete natural compounds that in turn are necessary to fight heart disease.

The third cause of CoQ10 deficiency is excessive use of the compound by the body. This again can be related to medications, aging or other causes such as excessive exertion, hypermetabolism, and acute shock states.

The real cause of CoQ10 deficiency is usually a combination of these three influences. It is likely that the average CoQ10 levels which have been observed in humans are suboptimal. In other words, the normal levels of CoQ10 that have become the standard for comparisons are very likely less than optimal. That would mean that the extremely low levels observed in connection with chronic diseases are just the worse case scenarios and that other less serious maladies are connected with lesser levels of deficiency.

If this sounds too much like laboratory theory, it isnâ??t. Patients who suffer from chronic diseases and also demonstrate extreme low levels of CoQ10 are not laboratory specimens. They are people who, in many cases, have been greatly helped by CoQ10 supplementation. If chronic disease is only the tip of the iceberg when it comes to CoQ10 deficiency one is forced to wonder what better diets and CoQ10 supplementing could do for the eradication of diseases and other chronic conditions.

Greg holds degrees in science, divinity and philosophy and is currently an I.T. developer.

http://www.optimal-heart-health.com/coq10.html


MORE RESOURCES:

Managing your medicines and supplements
Press-Enterprise
While living a healthy lifestyle goes a long way toward successfully managing one's overall well-being, adding medications and supplements to the mix may be necessary and helpful, says Kaiser Permanente family medicine expert Dr. Khaled M. Khoury.



Asbury Park Press

Owner of dietary supplements firm admits lying about ingredients, faces 5-year ...
Minneapolis Star Tribune
NEWARK, N.J. — Federal prosecutors say the owner of a New Jersey-based dietary supplements company has admitted his role in the sale of diluted and adulterated dietary ingredients and supplements. Barry Steinlight pleaded guilty Wednesday to ...
Owner Of Dietary Supplement Company Pleads Guilty To Multimillion-Dollar ...FailedMessiah.com
Not kosher: N.J. supplement maker admits lying about ingredientsNJ.com
NJ supplement maker admits lying about ingredientsAsbury Park Press
NutraIngredients-usa.com
all 66 news articles »


Dallas-based supplement maker faces federal investigation
Dallas Morning News
The Food and Drug Administration's criminal division is conducting a mail fraud investigation of USPlabs over misleading statements about its sports supplements, which are popular among fitness buffs and body builders, according to federal search warrants.



Glucosamine and chondroitin supplements show no effect on knee osteoarthritis
Washington Post
The results from X-rays and standardized scales rating pain, stiffness and function showed essentially no difference between those taking and not taking the supplements. Glucosamine/chondroitin neither relieved symptoms nor retarded progression of the ...



BBC News

Could a diet supplement supercharge your eyesight?
BBC News
In the past few years, researchers have found evidence that taking dietary supplements of these pigments could help to reduce glare and improve many other aspects of visual performance: sharper colours, enhanced contrast, faster recovery time, quicker ...



Doing your homework on nutritional supplements
U-T San Diego
Patients need to recognize that supplements can be quite potent and may interact with other drugs. Physicians need to create an open environment where patients feel comfortable discussing their supplement choices. Here are some thoughts that can help ...



Christian Post (blog)

Top Tips: How to Choose the Best Quality Nutritional Supplements
Christian Post (blog)
When it comes to health foods—notably vitamins and supplements—the saying “You get what you pay for” is often true. You work hard for your money and your health, so it's important you invest in effective, superior-quality supplements that work in ...

and more »


Men's Journal

The Problems With Supplements Pile Up: The Top Health & Fitness Moments of ...
Men's Journal
Dietary supplements took a beating in 2014. Big studies questioned whether multivitamins have any value. Dr. Oz got skewered on Capitol Hill for promoting bogus weight-loss products. Dangerous stimulants were found in sports supplements. And fallout ...



Defining 'Dietary Supplement' Gave Product Category Space to Grow
Natural Products INSIDER
Before the Dietary Supplement Health and Education Act of 1994 (DSHEA) was enacted 20 years ago, the U.S. supplement industry was homeless. It didn't have legal footing in the market, and companies selling ingredients to bolster dietary intake could ...

and more »


Forbes

Bee Pollen Supplements Stung By FDA, Contain Real Drugs
Forbes
If you're of a certain age, you may remember sprinters and short-distance runners taking bee pollen supplements around the time of the 1972 and 1976 Summer Olympics. Several U.S. and Scandinavian gold medalists touted the supplement as providing ...
Black Storm, Bee Thin, Bee Slim, Super Extreme Accelerator supplements ...cleveland.com

all 2 news articles »

Google News


Advertisement



Section Site Map - Submit News - Feedback - Comments - Advertise with Us

Copyright © 2006 Luminati Inc. All rights reserved.