Gavin Rees will take on Anthony Crolla in the chief support fight on the David Haye vs Manuel Charr show on June 29.
Welshman Rees returns to action for the first time after losing to WBC lightweight champion Adrien Broner in February.
Crolla, meanwhile, fought a draw with Derry Mathews in Liverpool last time and will be fighting in front of his home fans again at the Manchester Arena.
However, former British and European champion Rees will enter the fight as favourite as he looks to return to fighting at elite level.
"I cannot wait to get back into action," said Rees. "I am itching to get another world title shot after fighting Broner.
"He is a megastar and will go on to do massive things in the game, but I feel that I can win another world title and this is a massive fight to prove I still have ambitions at that level.
"Anthony is a very good fighter and he put up a great performance in his rematch with Derry Mathews, and I think that the draw was the fair result. All-British clashes are always great to be a part of, with my own battle against Mathews a real cracking fight.
"This fight has been on the cards for a while and I know that Anthony's trainer Joe Gallagher had his views on the fight when he said that Crolla was 'European champion without the belt'.
"I'm putting everything into practice that I learnt from the Broner experience and take out Crolla in his backyard."
British and Commonwealth champion Lee Selby will also feature on the undercard along with several other Matchroom fighters.