|The Lounge | Champions | The Wire | Schedule | Audio | Arcade | The Top Ten | Historical | Email | Video|
Fructose Short-Circuits Glycolysis
First some terminology.
Fructose ... a five carbon sugar that occurs naturally in fruit, does not cause as much insulin to be secreted as glucose and tastes sweeter than glucose.
Glucose ... a six carbon sugar that is the breakdown product of glycogen(a polymer of glucose, multiple glucose units hooked together) that occurs naturally in potatoes and grains.
Glycogen ... multiple units of glucose hooked together (a polymer).What is typically called "complex carbohydrate" today.
Glycolysis ... derived from the Greek stem glyk- "sweet" and lysis meaning dissolution. The metabolic pathway for the initial utilization of glucose.
Phosphofructokinase ... the enzyme that catalyzes the reaction offructose 6-phosphate to fructose 1,6-biphosphate. You don't need to understand anything more about this reaction otherthan the fact that if fructose comes from a source other thanthe degradation of glucose, it blocks this step for glucoseuntil all the non-glucose derived fructose has been metabolized.
Glucose and Fructose Are Both Metabolized via Gylcolysis
Both fructose and glucose are metabolized via glycolysis. Both end up at some point as three carbon fragments. In order for glucose to be broken down into three carbon fragments it must first be metabolized to a five carbon sugar, actually fructose. This is where the trouble starts, since fructose is already a five carbon sugar. The following analogy Ihope will aid in explaining this. The analogy, however, is far from perfect.
Whether we start out with separate glucose and fructose as inhigh fructose corn syrup or honey, or with fructose and glucose hooked together as in sucrose(common table sugar), makes nodifference. As soon as sucrose hits the bloodstream, it isimmediately broken down (hydrolyzed) to fructose and glucose.
Freda Fructose gets married to Gary (Glucose) Sucrose. They livehappily on Sugar Lane. Both work in muscle and liver cellswhere they are metabolized usually into fat and slow the immune system to a crawl. They get up early in the morningand both have to get on the Glycolysis Road to get to work. Gary (Glucose) is one carbon atom heavier than Freda Fructose and because of that, he cannot cross the river on one of the lighter and faster bridges on their way to work. Freda Fructose however, being lighter, has no problem crossing the faster bridge and making the short-cut to the Glycolysis Road. Gary Glucose, however, has to get on the road well above the short-cut, since he is too heavy to take the lighter bridge short-cut.
The Phosphofructokinase Intersection
As usual Freda Fructose gets to the Phosphofructokinase intersection well before Gary Glucose. By the time Gary Glucose gets to the intersection, the traffic directing policeman is once again allowing all the Freda Fructoses to make the turn onto Glycolysis Road while, all the Gary Glucoses can do is sit in traffic and wait. Once again, Gary, and all the other Glucoses on their way to work, must sit and wait for all the Freda Fructoses to get on Glycolysis Road before they can continue.
LA Traffic Control
Traffic control sees all these Glucoses sitting stuck in traffic, just like traffic backs up everyday in LA. It reacts by injecting a lot of green lights (insulin) into the pathway for the Glucoses to get to work. Finally, all the Fructoses pass and now because there are too many green lights, all the Glucoses pass quickly. All of the sudden there are no Glucoses to be found on the Glycolysis Road. All the cells along the way that used to be able to snag some Glucose can't because there isn't any. Whether it is the excessive insulin that isthe cause of so many of the lifestyle diseases we see todayor, all the backed up Gary Glucoses decide to cause theirown damage to the arteries they are in, I don't know. It is however, clearly established that the ingestion of sucrose (fructose and glucose) is related to many of our lifestyle diseases today including the extensive damage to the vascular system that occurs with adult onset diabetesmellitus. I know, my damaged arteries are up on this site.
Now you begin to feel lightheaded, dizzy and a bit disoriented.Traffic control has injected too many green lights and theconcentration of glucose drops precipitously. The brainstarts to complain because it no longer has enough glucoseto function. If the blood sugar gets low enough, seriouscomplications can occur.
Fructose and Glucose Together
The combination of fructose and glucose should be avoided asmuch as possible. When you eat your fruit, try to allow at least an hour or preferably two, before eating potatoes, whole grains or rice. Also avoid as much as you can sucrose,high fructose corn syrup, honey and maple syrup or, anysweetener that has as it main ingredients, fructose and glucose.
Brown Rice Syrup
Brown rice syrup is roughly about 45% maltose (two glucose unitshooked together), 50% complex carbohydrates and 3% glucose. Noglucose and fructose together but still sweet and I have knownsome people who can even get hypoglycemic from it.
Barley Malt Syrup
Made from whole barley it is about 65% Maltose and 30% complexcarbohydrates.
These are usually combinations of glucose, fructose and sucrose and should be avoided.
Maple syrup is about 65% sucrose and should be avoided.
Today's Health Tip:
If you want sweet, you are safest with stevia. Next would be sweeteners derived from rice and barley. Sucrose, high fructose corn syrup, maple syrup and fruit juice concentrates should be avoided.
Copyright John Mericle M.D. 2005 All Rights Reserved
One of our readers Wendy in the UK writes:
Just to let you know that according to the website below that takes you to Carol Bond Health Foods it is spelt Stevita. I couldn't find it anywhere on the site and through asking the chat section it was spelt differently. Thought you would like to know so that you can let the other newsletter recipients know.
PS Really enjoy the newsletter. Find it very informing so thank you. Gave up drinking milk last year after reading your article! Feel much healthier as a result.
To take Stevia for a test drive or purchase some onlinefollow the link below. I had luck just searching steviabut you could also search the product "Stevita."
DrMericle.com is devoted to achieving optimal health and peak performance through diet and lifestyle change. Dr. Mericle brings together a unique blend of formal training in organic chemistry and biochemistry, medical education, 29 marathons, 3 Hawaii Ironman competitions and a lot of practical real life experience.
Omega 3 Fat is Good for Your Heart and for Your Brain
Scandinavian fishermen are a healthy bunch. It had long been known that they live longer and have much less heart and blood-pressure related diseases than their European counterparts.
Nutrition Secrets Never Before Revealed
The topic of nutrition is one that is always present in our lives no matter where we turn. It's on the news, magazine articles, at school, at your doctor's office, and even is a major topic for many books.
Post Nasal Drip
Post nasal drip is a sensation of mucous build up in the throat. Sometimes you may even feel a dripping sensation from the back of your nose.
What's Causing Your Energy Drain?
This is such a busy time of year, isn't it? Whether it's school or after-school commitments, social or philanthropic organizations that start meeting again after the summer, end of the year plans at work, or all of the above, fall activities are demanding! If you're like me, you know you plan too much, but you still want to be efficient, accomplish everything, and do it well. There is no time in the schedule for running out of energy or getting sick, and "Collapse From Exhaustion" is not on the TO DO list.
Nutritional Support in Critically Ill Patients
The nutritional support in critically ill patients can be explained in 2 ways1.Enteral Nutrition2.
Vitamins and Minerals for a Healthy Reproductive System
Vitamins, minerals and other nutrients are essential to the development and proper performance of the reproductive system. Nutrition plays a vital role in the development and maturity of the reproductive system through childhood and adolescence and can even affect the endocrine system which regulates the hormones that rule the functions of the reproductive system.
Eating Outside Your Box
One way to combat the boredom many people complain accompanies eating healthy is to "eat outside your box," by experimenting with new foods and cuisines and by challenging your long held notions about what to eat and when. Iceberg is not the only kind of lettuce, apples and oranges aren't the only fruits and there is no law that says you can't eat mushroom lasagna for breakfast and a southwestern omelet for dinner.
Cholesterol Does Not Cause Heart Disease
Cholesterol is an essential building block of every cell in the body, required for all metabolic processes. It is particularly important in the production of nerve tissue, bile and certain hormones.
Essential Fatty Acids -The Good Fats
Fats (triacylglycerols) ..
What is Organic Food?
"Organic" has some quite specific legal definitions in most developed countries.In the U.
Did you know that there might be poison in many of your favorite foods found on grocery store shelves everywhere? Breads, crackers, cookies, energy bars, tortillas, frozen pizza are just a few examples of these dangerous foods. The poison in these items is called partially hydrogenated fat, often referred to as trans-fatty acids.
The coq10 Benefit
Coq10 is also known as Coenzyme Q10.This co q10 is produced naturally in the human body, and is a source of various coq10 benefit.
Simple Easy Health and Home Fixes From The Days Gone By
How did we cure ourselves of many aches pains and illnesses in the past?Most of the remedies worked very well, were cheap and could usually be found in most homes.Did you know that? Drinking two glasses of Gatorade can relieve headache pain almost immediately, without the unpleasant side effects caused by traditional "pain relievers.
The Secrets of the Centenarians: How to Live to 100!
When Helen Boardman was still a girlish 99, she fell in love again--with a younger man."I robbed the cradle," laughs the trim centenarian, who married a man twenty years her junior for "companionship," she says slyly.
Studies Prove Magnesium Boosts Memory & Learning Ability
According to the National Institute of Health, Magnesium is needed for more than 300 biochemical reactions, including maintenance of normal muscle and nerve function, strong bones and steady heart rhythm. It is also involved in energy metabolism and protein synthesis.
9 Tips to Stop Food Cravings and Help You With Your Diet
Most of us are "regular" people. We don't eat the perfect dietall the time and have our struggles with food, same as everyoneelse.
Six Ways Soy Benefits Your Health
Soy, and most soy-based products, are nutritional powerhouses. Soybeans are the only plant food that has all of the essential amino acids our body requires, making it a complete protein.
Set Your Fat Thermostat at a Healthy Level
Have you ever watched someone who appears thin and healthyeating a piece of chocolate cake and wondered how they staythin? Part of the reason is that they have a set-point intheir brain that keeps their body fat and weight fromvarying~ that is, until they do something that causes thebrain to change its settings for weight control.That's what happened to me when I quit smoking.
Learn the Basics of a Successful Low Cholesterol Diet
Understanding What a Low Cholesterol Diet isBasically, in order to lower your cholesterol, you will have to follow a diet that is? low in saturated fat and ? low in cholesterolThis is absolutely essential in helping you to lower your cholesterol. You must understand that although cholesterol lowering medications can be prescribed by your doctor, you will still need to follow a controlled diet specifically to help reduce your high blood cholesterol levels.
Can a Child Thrive on a Vegan Diet? YES!
Can a child thrive on a vegan diet? The answer is yes! Far more studies show that a typical 'Western Diet' has deleterious effects on health compared to the risks of a vegan diet. In fact, vegetarian diets are associated with disease resistance and even higher I.
Section Site Map - Submit News - Feedback - Comments - Advertise with Us
Copyright © 2006 Luminati Inc. All rights reserved.