Bookmark Website  | Free Registration  | The Team
The Lounge  | Champions  | The Wire |  Schedule |  Audio  |  Arcade  |  The Top Ten  |  Historical  |  Email  |  Video

Death, Aging, Rejuvenation (Part 1)


I would like to raise a question: Is Rejuvenation possible and how to approach it? This is just my own opinion about possible procedures. I used certain techniques based on a theory. As strange as it sounds some of those techniques and procedures might actually worked.

There are several hundreds theories of aging. New and old ones. Different authors classify them differently.

I would divide all those theories into 2 groups :

1. Theories of Deterioration from external cause. "Wear and tear". Theory of free radicals damage is most fashionable at present time. Antioxidants are considered a cure. Benefits of caloric restriction are often explained by that theory. The theory has good objective support in scientific literature. Other theories of this group included changes of bacteria in the gut, radiation and accumulation of mutations during life of an individual, etc. - many more of those theories were discussed in the XX century. 2. Internal clock - theories.

I would divide the "internal clock" theories into 2 more subgroups: 1. Internal clock on the level of cell. Telomeres shortening is the most discussed in literature at present. 2. Internal clock on the level of organism. Growth hormone changes was a recent example of discussion.

Authors are usually very cautious and objective in scientific literature. Telomeres are usually discussed in connection with "immortal" cancer cells. Caloric restriction is discussed as a mean of longevity (not rejuvenation per se). Level of growth hormone (GH) or insulin-like growth factor drops in aged persons.

Mass media speculates wider: telomeres restoration - possible immortal life, growth hormone will rejuvenate you, etc.

Original scientific studies usually do not speculate about this. In no way for example drop of GH level in elderly means that just giving it back will make you young again.

Scientific literature rarely discuss "Rejuvenation" as it is. Authors mostly talk about "longevity". This is very different story. Longevity in a wheelchair is very distinct from a youth playing soccer. One proven method to reach longevity is caloric restriction. Often they say it is the only proven technique. Using antioxidants as a method to prolong life is in the same category. To put simple, the Theory says: nutrition produce products of oxidation - peroxides, etc. These products damage DNA, proteins, etc. Cell ages. Caloric restriction switches metabolic pathways. There are less free radicals. Hence longevity. Antioxidants work in similar way - they remove free radicals. Another speculation is that caloric restriction starting at young age delays reproductive age in animals and this slows down biological clocks and prolongs life until an environment with high nutrition supply is found. Animals look small and undeveloped.

Caloric restriction significantly (25%-100% and more) prolonged life in worms, flies, spiders, rats, mice, etc. Experiments on monkeys and humans are under way and will take decades.

Well, it is all good in experiments and theories. Some argue: why in this case prisoners of concentration camps do not live longer. Another example came from "Scientific American" - a person had caloric restriction of something 20 years or more - no effect - he just looks like very thin undernourished person of 50 years. Examples of opposite opinion also exist (tribes or groups with low food consumption or high antioxidants consumption have more centenarians than general population). Maybe you really need to start at 10 years of age, look malnourished and weak for the whole life and live to 100 years, getting to your puberty at 25. Antioxidants also bring many controversy. Vitamin E did not show many benefits though it was a big hope for prevention of many diseases of old age. And so on. Today there are big trials that disprove the theory. Tomorrow - great experiments that confirm the theory, at least partially. Many big trials and experiments are published in leading journals - Science, Nature, PNAS, New England JM, JAMA, etc.

One bias for caloric restriction experiment in my opinion is following. Rats live in cage 30cmX60cm for their whole life. There are at least five rats or 20 mice. They live couple years and die. During the experiments they are celebrities when they live 5 years - some lucky ones. The Food is a balanced mixture of nutrition. Caloric restriction is - 60% of their regular meal. They practically don't move - there is no space in cage. Mostly they sleep whole day. Sometime they fight and mate. They live in those conditions at Yale, at Med U of South Carolina, at Russian State Medical University and I think everywhere else. To compare our fellow humans we would place 10 people on area of 20 square metres (200 sq. feet) for 50 years in a row, feeding them with what they want but all the same - let say junk food from McDonalds.

I remember my cat (who was partially wild) stole meat and ate until it started to vomit. He repeated it many times when he was able to steal some steak or whatever. The same happens in wild - lions have maybe one successful hunt out of ten. When they catch a prey, they eat like crazy. Much more than they can digest at the moment. So it looks like there is an instinct. Eat as much as possible. This is not a joke - 60% of people in western countries are overweight. Abundant high calorie food and lack of activity. It does not seem that for these people any internal mechanism restricts food consumption. Applying this back to rats, we can see that what is considered normal consumption - "ad lib" - maybe actually big overfeeding of the animals in these cages.

In this case 60% of caloric restriction would be just what rats need, just what the calories they spend in lazy, uneventful daily life. So called "control", "normal" rats - that fed as they usually fed might be compared for fat overweight humans. They consume junk food. They prone to the bunch of diseases of obesity and low activity. Heart diseases, strokes, variety of cancers, arthritis, etc.

In this case all the hype about caloric restriction would just be brought to the business of mere balancing diet and activity in so called "calorie-restricted animals". I haven't seen any discussion of this problem. I might be wrong. This is why I use caloric restriction for myself. I did not work with worms and spiders. But my guess would be that they all are also in artificial standardized conditions. "Control" worms might be also overfed. To put rats into bigger cages (to increase activity in control group and balance calories and catabolism) would be incredibly expensive.

Even at present conditions because of "animal lovers" and bunch of other regulations and considerations (e.g. sterile conditions), the price of animal housing is sky-high.

You would say animals in wild would live longer because they balance activity and consumption. Well, recently I read that life span of animals in wild is shorter than animals in captivity. Correct me if I am wrong: pandas live 15-20 years in nature and 20-30 in zoos, bears 20-25 in nature and 30-40 in captivity. Civilization has certain benefits - vaccinations, good medical care, more or less good hygiene. So just moving into wild conditions wouldn't make you younger or allow to live longer.

Now, to discuss rejuvenation procedures, I would need to talk about aging first. In this case Rejuvenation could be considered as reversal of aging (deterioration). Longevity is different story - it is prolonged life span. Rejuvenation supposedly should lead to longevity. But longevity is not equal to Rejuvenation. Aging leads to Death eventually. It is easier to discuss from that end.

All written here is just plain speculation, take it with a grain of salt.

- continued in Part 2

About The Author

Aleksandr Kavokin, MD,PhD

http://www.geocities.com/aging_rejuvenation/

http://www.geocities.com/usmle_test

aging_rejuvenation@yahoo.com


MORE RESOURCES:

EU steps up on food security
Devex
EuropeAid funds programs, projects and actions all over the world that deal with sustainable and equitable food security measures. It is also a strong supporter of the global Scaling Up Nutrition movement, which aims to improve nutrition through a ...

and more »


Bridges will offer nutrition program
The Times (subscription)
The nutrition program Eating Smart, Being Active, will be offered at Bridges Senior Center, 221 W. Etna Road, Ottawa, through University of Illinois Extension. Sessions will run from 11:15 a.m. to 12:30 p.m. Tuesdays, Aug. 5 and 12. Registration is ...



A HEALTHY Potato Chip? Quest Nutrition Launches Quest Protein Chips!
Broadway World
Quest Nutrition introduces the world's first high-protein snack potato chip, offering consumers a revolutionary potato chip experience that's actually good for you instead of being just "less bad." Quest Protein Chips are the latest innovation from the ...

and more »


Nutrition Facts Label May Take a Hard Line on Sugar
Roll Call
Earlier this year, the Food and Drug Administration unveiled a revamped Nutrition Facts label for food packages, proposing changes to the iconic white box for the first time since it was adopted 20 years ago. Among the adjustments: a bolder calorie ...

and more »


Our Views: La. fighting nutrition battle
The Advocate
We know much about these problems because of the internationally recognized research at LSU's Pennington Biomedical Research Center, based in Baton Rouge but with a statewide and national mission of promoting nutrition. We also see commendable ...

and more »


Businessweek

Dog Food Fight! Purina Says Blue Buffalo Is 'Built on Lies'
Businessweek
Guest host Seth Rogen and SNL cast member Cecily Strong played the sort of overwrought consumers who philosophize about pet nutrition in Blue Buffalo's actual ads. The characters suffer an emotional meltdown as they discuss what they've fed their ...



New York Times (blog)

A Dietitian Who Won't Oversell Nutrition to Her Kids
New York Times (blog)
Instead, it goes on a separate plate in case they change their mind or want to learn more about the food, which is often new or unfamiliar. Why abstain from nutrition lessons while they are eating? Because one of my goals is to raise children who eat ...



AmmoLand.com

Nutrition Standards Could Create Regulatory Potluck
Farm Futures
Think meat and protein are a healthy component of a nutritious diet? Input on dietary guidelines are beginning to urge that consumption of eating less meat should be pursued not for health reasons, but for the environment. Every five years a panel of ...
Caruba: Should the Government Tell You What to Eat?AmmoLand.com (press release)
Is Dietary Variety Overrated?Triathlete Europe

all 6 news articles »


Xtri.com

Race day nutrition tips
Xtri.com
Race day nutrition is extremely important in long distance triathlon. If nutrition is not well planned it can derail your race. The fittest triathletes in the world cannot overcome the lack of proper nutrition on race day. Issues related to nutrition ...



New York Times

Ackman Goes After Herbalife's Nutrition Clubs
ABC News
In a three-hour presentation in New York, Ackman's focused on Herbalife's "nutrition clubs," private settings where Herbalife distributors sell the company's products — such as weight-loss shakes — and recruit new members. Ackman laid out a case that ...
Bill Ackman Slams Herbalife's Nutrition Clubs: 'It's a Pyramid Scheme'DailyFinance

all 430 news articles »

Google News


Advertisement



Section Site Map - Submit News - Feedback - Comments - Advertise with Us

Copyright 2006 Luminati Inc. All rights reserved.