Promoter Eddie Hearn has opened talks with IBF champion Miguel Vazquez about facing Kevin Mitchell on the Carl Froch-George Groves undercard.
The Dagenham fighter will be targeting a fourth straight win this Saturday against Georgian Mikheil Avakyan in a bumper Liverpool bill, live on Sky Sports.
A stoppage defeat by Ricky Burns wrecked Mitchell's hopes of taking the WBO belt in 2012, but he has impressed since a reunion with old trainer Tony Sims and Hearn feels he is ready to fight at world level again.
Bitter rivals Froch and Groves will collide again in the capital on May 31, live on Sky Sports Box Office, and the inclusion of a lightweight world title fight would add more excitement to a big night for British boxing at Wembley.
"We are talking to Kevin Mitchell, we're talking to Miguel Vazquez as well the IBF champion about a potential shot for him," said Hearn.
"He's (Mitchell) ready for the step-up. He was supposed to fight Tommy Coyle, but Tommy Coyle had a really tough fight in his last fight and he may be moving up to light-welterweight. It's going to be interesting to see, but Mitchell's ready for a big fight.
"I made some approaches to them (Vazquez's promoters). We're making him an offer, we're talking money with them at the moment, so it's a fight we would like to make."
Hearn is also keen to secure another world title fight and has approached Stuart Hall about defending his IBF bantamweight title against Jamie McDonnell.
McDonnell was stripped of the IBF belt after failing to agree a mandatory defence and Hall won the vacant strap with a battling points win over Vusi Malinga in December.
"I've made Stuart Hall a huge offer to fight Jamie McDonnell and hopefully he will take that. I would think he would want to fight on the show," said Hearn.
Exciting heavyweight Anthony Joshua is expected to fight at Wembley and Larry Olubamiwo is being considered as a possible future opponent for the Olympic gold medallist.