Early in the course of the disease, the most obvious symptoms are movement-related; these include shaking, rigidity, slowness of movement and difficulty with walking and gait. Later, cognitive and behavioural problems may arise, with dementia commonly occurring in the advanced stages of the disease.
Modern treatments are effective at managing the early motor symptoms of the disease. As the disease progresses these drugs eventually become ineffective at treating the symptoms and at the same time produce a complication called dyskinesia, marked by involuntary writhing movements.
Finally, after ten years most people with the disease have autonomic disturbances, sleep problems, mood alterations and cognitive decline. All of these symptoms, especially cognitive decline, greatly increase disability
Muhammad Ali has been called the "world's most famous Parkinson's patient". He was 42 at diagnosis although he showed signs of Parkinson's when he was 38.Whether he has PD or a parkinsonian syndrome caused by boxing is unresolved
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