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#1
Old 12-18-2009, 07:59 PM
Oasis_Lad
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Default Scientists crack 'entire genetic code' of cancer

Scientists have unlocked the entire genetic code of two of the most common cancers - skin and lung - a move they say could revolutionise cancer care.

Not only will the cancer maps pave the way for blood tests to spot tumours far earlier, they will also yield new drug targets, says the Wellcome Trust team.

Scientists around the globe are now working to catalogue all the genes that go wrong in many types of human cancer.

The UK is looking at breast cancer, Japan at liver and India at mouth.

China is studying stomach cancer, and the US is looking at cancers of the brain, ovary and pancreas.

The International Cancer Genome Consortium scientists from the 10 countries involved say it will take them at least five years and many hundreds of thousands of dollars to complete this mammoth task.

But once they have done this, patients will reap the benefits.

Professor Michael Stratton, who is the UK lead, said: "These catalogues are going to change the way we think about individual cancers.

"By identifying all the cancer genes we will be able to develop new drugs that target the specific mutated genes and work out which patients will benefit from these novel treatments.

"We can envisage a time when following the removal of a cancer cataloguing it will become routine."

It could even be possible to develop MoT-style blood tests for healthy adults that can check for tell-tale DNA patterns suggestive of cancer.

Russian roulette

The scientists found the DNA code for a skin cancer called melanoma contained more than 30,000 errors almost entirely caused by too much sun exposure.

The lung cancer DNA code had more than 23,000 errors largely triggered by cigarette smoke exposure.

From this, the experts estimate a typical smoker acquires one new mutation for every 15 cigarettes they smoke.

Although many of these mutations will be harmless, some will trigger cancer.

Wellcome Trust researcher Dr Peter Campbell, who conducted this research, published in the journal Nature, said: "It's like playing Russian roulette.

"Most of the time the mutations will land in innocent parts of the genome, but some will hit the right targets for cancer."

By quitting smoking, people could reduce their cancer risk back down to "normal" with time, he said.

The suspicion is lung cells containing mutations are eventually replaced with new ones free of genetic errors.

By studying the cancer catalogues in detail, the scientists say it should be possible to find exactly which lifestyle and environmental factors trigger different tumours.

Treatment and prevention

Tom Haswell, who was successfully treated 15 years ago for lung cancer, believes the research will benefit the next generation:

"For future patients I think it's tremendous news because hopefully treatments can be targeted to their particular genome mutations, hopefully... reducing some of the side effects we get".

Cancer experts have applauded the work.

The Institute of Cancer Research said: "This is the first time that a complete cancer genome has been sequenced and similar insights into other cancer genomes are likely to follow.

"As more cancer genomes are revealed by this technique, we will gain a greater understanding of how cancer is caused and develops, improving our ability to prevent, treat and cure cancer."

Professor Carlos Caldas, from Cancer Research UK's Cambridge Research Institute called the research "groundbreaking".

"Like molecular archaeologists, these researchers have dug through layers of genetic information to uncover the history of these patients' disease.

"What is so new in this study is the researchers have been able to link particular mutations to their cause.

"The hope and excitement for the future is that we will eventually have detailed picture of how different cancers develop, and ultimately how better to treat and prevent them."

http://news.bbc.co.uk/1/hi/health/8414124.stm
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#2
Old 12-18-2009, 08:06 PM
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Surprise, surprise. All one needs to do is quit smoking.

That is hardly a major discovery.
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#3
Old 12-18-2009, 08:16 PM
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This is good news! Hopefully a cure for cancer will be here soon...
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#4
Old 12-18-2009, 08:52 PM
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Surprise, surprise. All one needs to do is quit smoking.

That is hardly a major discovery.
To reduce your risk, yes. Not to prevent you from getting cancer entirely.
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#5
Old 12-18-2009, 09:22 PM
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To reduce your risk, yes. Not to prevent you from getting cancer entirely.
I'm more inclined to believe the cure was found ages ago and not recently.
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#6
Old 12-18-2009, 09:30 PM
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This is pretty ****ing awesome
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Old 12-18-2009, 09:37 PM
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Isn't this old news? I mean Lung-Cancer is old news!
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Old 12-18-2009, 09:45 PM
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Cancer is common u find it in animals as well, and there is still some huge fuken mythical ignorance about cancer concerning ignorant laymans like a majority of layman college students and teachers and religous nuts saying there was no cancer in ancient times/ biblical-times and that cancer only started during the industrial era as a result of modern diet, plastics and chemical pollution in the air. But the fact is it is not new it has always been there LOL!
-----------------------------------------------------------------------
The First Documented Case of Cancer
The world's oldest documented case of cancer hails from ancient Egypt, in 1500 b.c. The details were recorded on a papyrus, documenting 8 cases of tumors occurring on the breast. It was treated by cauterization, a method to destroy tissue with a hot instrument called "the fire drill." It was also recorded that there was no treatment for the disease, only palliative treatment.

There is evidence that the ancient Egyptians were able to tell the difference between malignant and benign tumors. According to inscriptions, surface tumors were surgically removed in a similar manner as they are removed today.
----------------------------------------------------------------

I have a hunch that the implications are even far wider than we know or imagine, cancer could be caused by random events you have no total control of... like cosmic rays and others cosmic particles causing random quantum mechanical mutations in the atoms and molecules in your body that no matter how clean of cancer your heredity is or your diet is you will get cancer still to this radical random factors.
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Old 12-18-2009, 09:46 PM
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The International Cancer Genome Consortium scientists from the 10 countries involved say it will take them at least five years and many hundreds of thousands of dollars to complete this mammoth task.

"By identifying all the cancer genes we will be able to develop new drugs that target the specific mutated genes and work out which patients will benefit from these novel treatments.
This is the objective.
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Old 12-18-2009, 10:11 PM
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Surprise, surprise. All one needs to do is quit smoking.

That is hardly a major discovery.
Or sucking ****. Neither of which I'm prepared to do. I love a toot after delivering a killer BJ.
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