At what time? 2000? Like instead of Tua it's Ike? Lewis would have dominated him the same way he toyed with Tua.
But if Ike haven't gone bat shyt crazy and continued to progress as a fighter, clean up Wlad and take Vitali's place that night at Staples. Lewis would have gotten knocked out.
Ike would have hit his prime right around the time Lennox was eating himself into an boxing grave... and a 260 Pound Lewis would have gotten beaten.