Nope, the fight will be easier to make with a Floyd loss. Manny does like to fight fighters coming out of losses and Floyd might drop his demand because he has nothing to protect.
But, seriously a loss for Mayweather will be good for him psychologically. He's really full of himself with that zero. His whole being is about that zero. He's acting up because of that zero. He's making demands to protect that zero. I don't want to see this genius go off the grid because he never learned coping skills from that zero.