By TMZ Sports

Josie Harris, who has 3 kids with Floyd Mayweather Jr., has filed a lawsuit for defamation in connection to an interview with Katie Couric conducted two weeks ago... when he claimed Josie was in a drug-fueled rage and he had to "restrain" her during their infamous 2010 domestic violence incident. Mayweather spent two months in jail as a result of their confrontation.

She claims in the lawsuit that Mayweather's version of the story has now destroyed her image and has people labeling her as a drug addict. 

Her lawyer, Dan Friedlander, writes in the lawsuit -- Floyd's details of the incident to Couric "were knowingly fabricated in order to hype Mayweather's upcoming fight with Pacquiao, to avoid bad press by deflecting responsibility for beating the mother of his children."

Harris wants in excess of $20 million.